Inhaled Antimuscarinics/Anticholinergics

Question 1

MOA

Answer 1

• bind to M3 (smooth muscle)
• antagonize ACh actions at these sites
• bronchodilation

Question 2

what are the 2 types of inhaled antimuscarinics/anticholinergics?

Answer 2

• SAMA (short-acting muscarinic antagonist)

- LAMA (long-acting muscarinic antagonist)

Question 3

tell me about SAMAs

Answer 3

• onset is 15-20 min

- effects last 6-8 hours

Question 4

tell me about LAMAs

Answer 4

effects last 12-24 hours

Question 5

AEs for inhaled antimuscarinics/anticholinergics

Answer 5

• very well tolerated

- dry mouth is the only AE

Question 6

drug names to be familiar with

Answer 6

• tiotropium (Spiriva)

- this drug is a LAMA