Prostate Cancer

Question 1

When does most prostate cancer occur? When is t most aggressive?

Answer 1

• 85% occurs after 65 yrs

- Very aggressive in young individuals

Question 2

T or F:

The progression of prostate cancer is slow

Answer 2

F, it spreads quickly and metastasizes early

- No early mnfts

Question 3

What are risks for prostate cancer?

Answer 3

• Aging
• Ethnicity (increased risk in African people)
• Diet
• Family Hx (1st and 2nd degree relatives)
• Androgens

Question 4

What type of tumor is prostate cancer usually due to? Give a few characteristics of this type.

Answer 4

• Usually adenocarcinoma
• Peripheral
• Multicentric
• Varied forms

Question 5

Where does prostate cancer extend to? Where does it metastasize to?

Answer 5

• The bladder neck and the seminal vesicles

- Mets to the lungs, liver, skeleton

Question 6

What are some common mnfts with prostate?

5

Answer 6

Mnfts occur following invasion/metastasis

• Dysuria
• Hematuria
• Pain/difficulty urinating
• Prostatitis
• Back pain

Question 7

What are the Dx for prostate cancer?

5

Answer 7

• Hx, Px
• DRA (screen)
• Prostate specific antigen (screen and Dx)
• US
• Biopsy

Question 8

What is the 1st line of Tx for prostrate cancer? What are the other Tx options?

Answer 8

Androgens eg estrogen

• These are not curative, but because this is a tumor relying on hormone, if you cut of its hormone supply it will limit the growth and synthesis of DHT
• Radical prostectomy
• Radiation