Glomerular Disease Flashcards
1
Q
What is the glomerulus? What are 3 of its Fxs?
A
- The glomerulus is a network of capillaries
1. Ultrafiltration - Filtering under high pressure
- Blood is concentrated because vessels are larger as it enters the glomerulus and get smaller = Increased pressure
2. Reabsorption
3. Secretion
2
Q
What type of hypersensitivity is glomerular disease? Why is this?
A
- Type 3 hypersensitivity
- Usually immune based
- Could be a result of Abs binding to Ags on cell wall
3
Q
What are the 5 clinical presentations of glomerular disease?
A
- Acute nephritic syndrome
- Nephrotic syndrome
- Asymptomatic proteinuria + hematuria
- Acute glomerular nephritis
- Chronic glomerular nephritis
4
Q
Describe acute nephritic syndrome:
A
- Decreased permb
- Decreased glomerular filtration
- Fluid retention and azotemia
- HTN and edema
5
Q
Describe nephrotic syndrome:
A
- Increased glomerular filtration
- Proteinuria, hypoalbuminemia
- Less albumin = less OP - Hyperlipidemia and lipiduria
- More lipids in blood = more lipids in urine
- Proteinuria, hypoalbuminemia
6
Q
Describe asymptomatic proteinuria and hematuria
names a dead giveaway…
A
- No symptoms of glomerular disease
- Proteinuria more pronounced than in nephrotic
syndrome - No impairment of kidney fx
7
Q
Describe acute glomerular nephritis:
A
Acute inflm of the glomeruli
8
Q
Describe chronic glomerular nephritis:
A
Chronic inflm of the glomeruli
9
Q
Who is most effected by acute post-infctous glomerular nephritis?
A
Effects all ages, but has worse outcomes in adults
95% of children recover
10
Q
What sort of infct is present prior to contraction of post infctous glomerular nephritis?
A
Dermal or pharyngeal infct (7-12 days)
- Beta hemolytic strep
- Lysis of RBCs
- Alpha hemolytic strep
- Not complete lysis, converts Hgb to met Hgb
- Adds an additional charge = becomes ferric
