Inflammatory Bowel Disease Flashcards
What are the 2 chronic types of inflm bowel disease (IBD)?
- Crohn’s Disease
- Ulcerative Colitis
What is the Et of IBD?
3 things
- Genetic susceptibility
- Losing tolerance to normal flora
- An environmental trigger ? (some other type of bacterial
infct)
What type of autoimmunity is seen in Crohn’s?
It is not a type of autoimmunity. There is l/o tolerance to normal flora, but this is not considered autoimmunity because it is not l/o tolerance to our own cells, just the bacteria in our gut.
What area is primarily affected in Crohn’s Disease?
The submucosa in the terminal ileum.
What types of lesions are seen with Crohn’s?
Granulomas.
What is another word used to describe the granulomas in Crohn’s?
Skip lesions.
T or F:
Crohn’s progresses very fast, making it more difficult to manage than Ulcerative Colitis.
F
It progresses slowly, making it more manageable.
What are some mnfts commonly seen with Crohn’s?
- Diarrhea
- Abdm pain
- Fluid-‘lyte imbalance
- Weight loss
What is there wt loss in people with Crohn’s?
Because there is a decrease in absorptive surface in the intestine, which allows for less absorption of nutrients.
What are 3 complications that may arise from Crohn’s?
- Fistulas
- Abscesses
- Bowel obstruction
What area of the gut is primarily affected by Ulcerative Colitis?
The mucosa in the colon and rectum.
Explain the progression pattern of Ulcerative Colitis:
Progresses proximally from the rectum
Describe the lesions seen in pts with Ulcerative Colitis:
Thickened and inflmed bleeding ulcers, continuous lesions unlike the “cobblestone” pattern in Crohn’s.
With Ulcerative Colitis, there is ______ and ______ in the colon.
Edema and congestion.
In Ulcerative Colitis, what structures in the colon will collect exudate? What does this collection result in?
The Crypts of Lieberkuhn collect exudate, forming crypt abscesses.
What is an abscess?
Define scientifically
A collection of pus or purulent exudate that has built up within the tissue of the body.
What are pseudoployps?
They are not polyps, these are areas of raised granulation tissue.
What are some mnfts seen in pts with Ulcerative Colitis?
- Bloody diarrhea
- Abdm cramping
- Wt loss
Why is there wt loss in people with Ulcerative Colitis?
They may have a decreased desire for food because of the symptoms accompanying.
What are the Dx for IBD?
- Hx and Px
- Colonoscopy
- Biopsy
- Labs to exclude infct
What is the Tx of IBD?
Depends on the severity
- Diet
- Anti-inflm
- Immunoregulatory drugs
- Abx ??
- Sx ??
What is a specific example of an anti-inflm you would use for Tx of IBD?
Sulfasalazine.
Why wouldn’t you use NSAIDs for Tx of IBD?
Because NSAIDs can have adverse side effects on the stomach.
If the pt is non-responsive to the anti-inflms, what should be given instead? Why are these not the first choice for anti-inflm?
Steroids. These are not the first choice because steroids should not be used long-term.
What is an example of an immunoregulatory drug that can be used for Tx of IBD?
Methotrexate.
