Inflammatory Bowel Disease Flashcards

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1
Q

What are the 2 chronic types of inflm bowel disease (IBD)?

A
  • Crohn’s Disease

- Ulcerative Colitis

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2
Q

What is the Et of IBD?

3 things

A
  1. Genetic susceptibility
  2. Losing tolerance to normal flora
  3. An environmental trigger ? (some other type of bacterial
    infct)
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3
Q

What type of autoimmunity is seen in Crohn’s?

A

It is not a type of autoimmunity. There is l/o tolerance to normal flora, but this is not considered autoimmunity because it is not l/o tolerance to our own cells, just the bacteria in our gut.

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4
Q

What area is primarily affected in Crohn’s Disease?

A

The submucosa in the terminal ileum.

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5
Q

What types of lesions are seen with Crohn’s?

A

Granulomas.

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6
Q

What is another word used to describe the granulomas in Crohn’s?

A

Skip lesions.

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7
Q

T or F:

Crohn’s progresses very fast, making it more difficult to manage than Ulcerative Colitis.

A

F

It progresses slowly, making it more manageable.

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8
Q

What are some mnfts commonly seen with Crohn’s?

A
  • Diarrhea
  • Abdm pain
  • Fluid-‘lyte imbalance
  • Weight loss
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9
Q

What is there wt loss in people with Crohn’s?

A

Because there is a decrease in absorptive surface in the intestine, which allows for less absorption of nutrients.

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10
Q

What are 3 complications that may arise from Crohn’s?

A
  • Fistulas
  • Abscesses
  • Bowel obstruction
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11
Q

What area of the gut is primarily affected by Ulcerative Colitis?

A

The mucosa in the colon and rectum.

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12
Q

Explain the progression pattern of Ulcerative Colitis:

A

Progresses proximally from the rectum

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13
Q

Describe the lesions seen in pts with Ulcerative Colitis:

A

Thickened and inflmed bleeding ulcers, continuous lesions unlike the “cobblestone” pattern in Crohn’s.

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14
Q

With Ulcerative Colitis, there is ______ and ______ in the colon.

A

Edema and congestion.

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15
Q

In Ulcerative Colitis, what structures in the colon will collect exudate? What does this collection result in?

A

The Crypts of Lieberkuhn collect exudate, forming crypt abscesses.

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16
Q

What is an abscess?

Define scientifically

A

A collection of pus or purulent exudate that has built up within the tissue of the body.

17
Q

What are pseudoployps?

A

They are not polyps, these are areas of raised granulation tissue.

18
Q

What are some mnfts seen in pts with Ulcerative Colitis?

A
  • Bloody diarrhea
  • Abdm cramping
  • Wt loss
19
Q

Why is there wt loss in people with Ulcerative Colitis?

A

They may have a decreased desire for food because of the symptoms accompanying.

20
Q

What are the Dx for IBD?

A
  • Hx and Px
  • Colonoscopy
  • Biopsy
  • Labs to exclude infct
21
Q

What is the Tx of IBD?

A

Depends on the severity

  • Diet
  • Anti-inflm
  • Immunoregulatory drugs
  • Abx ??
  • Sx ??
22
Q

What is a specific example of an anti-inflm you would use for Tx of IBD?

A

Sulfasalazine.

23
Q

Why wouldn’t you use NSAIDs for Tx of IBD?

A

Because NSAIDs can have adverse side effects on the stomach.

24
Q

If the pt is non-responsive to the anti-inflms, what should be given instead? Why are these not the first choice for anti-inflm?

A

Steroids. These are not the first choice because steroids should not be used long-term.

25
Q

What is an example of an immunoregulatory drug that can be used for Tx of IBD?

A

Methotrexate.