Cirrhosis

Question 1

What is cirrhosis?

Answer 1

A complication of severe liver disease

Question 2

What happens to the liver with cirrhosis?

Answer 2

Degenerative nodular liver with diffuse fibrosis

Question 3

Cirrhosis is a leading cause of _______

Answer 3

Death

Question 4

What is the link between alcoholism and hepatitis?

Answer 4

Alcoholism contributes to 60-70% of cirrhosis

Question 5

What is the Et of cirrhosis?

Answer 5

• Alcoholism
• Viral hepatitis
• Biliary obstruction
• Metabolic disorders
• Toxic drugs

Question 6

What is an example of a metabolic disease that may contribute to cirrhosis? Explain how it contributes.

Answer 6

Wilson disease

- Copper accumulates and deposits in vital organs

Question 7

Explain the patho of cirrhosis in 5 steps:

dis a longggg one

Answer 7

1. Hepatocyte necrosis = fibrosis around regenerating cells = nodular, non-Fx tissue
2. Fibrosis = constricted vessels = altered perfusion = portal HTN = fluid shift = ascites
3. Ducts constricted = bile stasis
4. Metabolic waste clearance impeded
5. Liver failure :/

Question 8

What are the mnfts of cirrhosis?

Answer 8

• Anorexia
• Weakness
• Wt loss
• Jaundice
• Hepatomegaly

Question 9

T or F:

Jaundice may be absent in some forms of cirrhosis

Answer 9

T

Question 10

What are complications of cirrhosis?

Answer 10

• Portal HTN
• Ascites
• Varices rupture
  
  • Massive hemorrhaging
• Splenomegaly

Question 11

Why might there be splenomegaly accompanying cirrhosis?

Answer 11

The spleen is overworked because the slower blood flows, the longer blood takes to move in and out of the spleen, and in the meantime the more RBCs are recycled by the spleen

Question 12

What is the Tx for cirrhosis?

Answer 12

To facilitate regeneration

• Diet should consist of small, high calorie meals
• NO alcohol