Principles of Chemotherapy W5

Question 1

Steps prior to treatment

Answer 1

Self detect -> referral -> diagnosis

Question 2

NHS treatment targets

Answer 2

▪ Urgent referral 2 week wait between seeing GP and start of investigations
▪ No more than 2 months ( 62 days) wait between urgent referral and start of treatment
▪ No more than 31 days between diagnosis and start of treatment

Question 3

Treatment decisions

Answer 3

Surgery
Radiotherapy
Systemic anti cancer therapy
Hormonal manipulation
Supportive care

Question 4

Intent of treatment with SACT

Answer 4

Curative - aggressive

Palliative - prolong life and reduce symptoms

Subsequent line - treatment for reoccurant

Question 5

Neoadjuvant

Answer 5

Given before surgery to decrease tumor size

Question 6

Adjuvant

Answer 6

Given after surgery

Question 7

Concomitant

Answer 7

With radiotherapy to mop up an cancer cells

Question 8

Important considerations

Answer 8

Patient:
- performance status
- age
- previous treatment
- co-morbidities
- polypharmacy

Question 9

Treatment delivery

Answer 9

Combo therapy

Combination

Question 10

Monitor response to treatment

Answer 10

Lump in lymph’s can be felt and measures physical examination

Some tumors can show on x-ray or CT

Can be with bloods

Question 11

Targeted therapy

Answer 11

Monoclonal antibodies

Antibody drug conjugates

Tyrosine kinase inhibitors

CKS inhibitors

Question 12

Hormone therapy

Answer 12

Remove the hormone that feeds the tumor to grow