Antidiabetics 1 W3 Flashcards
1
Q
Pharmacological target
A
DPP-4
Dipeptiddyl peptidase 4
2
Q
Half life of GLP-1
A
Short
<2mins because it is rapidly inactivated in the plasma by DPP-4
3
Q
What do DPP-4 inhibitors do
A
Increase glucose-dependant insulin secretion
4
Q
What does inhibition of DPP-4 do
A
Decreases breakdown of GLP-1 so it can perform it biological actions longer
5
Q
A
