Antidiabetics 2 W3

Question 1

2 classes of antidiabetic drugs

Answer 1

1. Biguanides - metformin
2. Sulfonylureas - gliclazide

Question 2

Metformin

Answer 2

Lowers basal and post-pradnial blood glucose conc

Makes liver produce less glucose

does not stimulate insulin release, so it has a low risk of hypoglycemia.

Question 3

Metformin pharmacological mechanisms of action

Answer 3

Inhibits Hepatic Gluconeogenesis

Activates AMPK

Improves Insulin Sensitivity

Decreases Intestinal Glucose Absorption

Question 4

Metformin Inhibits …

Answer 4

1. complex 1 of the respiratory chain in mitochondria

= This means less ATP production and more AMP which activated AMPK

2. Hepatic gluconeogenesis

= lowers fasting blood G

Question 5

PPARγ agonists

Answer 5

nuclear receptor found in adipose tissue

activate the PPARγ receptor, which:

1.Improves insulin sensitivity in adipose tissue, muscle, and liver
2. Reduces insulin resistance