Antidiabetics 2 W3 Flashcards
(5 cards)
1
Q
2 classes of antidiabetic drugs
A
- Biguanides - metformin
- Sulfonylureas - gliclazide
2
Q
Metformin
A
Lowers basal and post-pradnial blood glucose conc
Makes liver produce less glucose
does not stimulate insulin release, so it has a low risk of hypoglycemia.
3
Q
Metformin pharmacological mechanisms of action
A
Inhibits Hepatic Gluconeogenesis
Activates AMPK
Improves Insulin Sensitivity
Decreases Intestinal Glucose Absorption
4
Q
Metformin Inhibits …
A
- complex 1 of the respiratory chain in mitochondria
= This means less ATP production and more AMP which activated AMPK
- Hepatic gluconeogenesis
= lowers fasting blood G
5
Q
PPARγ agonists
A
nuclear receptor found in adipose tissue
activate the PPARγ receptor, which:
1.Improves insulin sensitivity in adipose tissue, muscle, and liver
2. Reduces insulin resistance