Antidiabetics 2 W3 Flashcards

(5 cards)

1
Q

2 classes of antidiabetic drugs

A
  1. Biguanides - metformin
  2. Sulfonylureas - gliclazide
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2
Q

Metformin

A

Lowers basal and post-pradnial blood glucose conc

Makes liver produce less glucose

does not stimulate insulin release, so it has a low risk of hypoglycemia.

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3
Q

Metformin pharmacological mechanisms of action

A

Inhibits Hepatic Gluconeogenesis

Activates AMPK

Improves Insulin Sensitivity

Decreases Intestinal Glucose Absorption

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4
Q

Metformin Inhibits …

A
  1. complex 1 of the respiratory chain in mitochondria

= This means less ATP production and more AMP which activated AMPK

  1. Hepatic gluconeogenesis

= lowers fasting blood G

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5
Q

PPARγ agonists

A

nuclear receptor found in adipose tissue

activate the PPARγ receptor, which:

1.Improves insulin sensitivity in adipose tissue, muscle, and liver
2. Reduces insulin resistance

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