Antidiabetics 3 W3

Question 1

Two classes of anti diabetic drugs that act ar targets involved in the absorption of glucose in the GIT and reabsorbtion in the kidneys

Answer 1

• Sodium glucose co-transporter 2 (SGLT-2) inhibitors eg:
dapagliflozin
• α-glucosidase inhibitors eg: acarbose

Question 2

Target of SGLT-2

Answer 2

Sodium glucose co-transporter 2

It mediated the reabsorbtion of G in the kidneys

Question 3

What do inhibitors of SGLT2 do

Answer 3

Reduces reabsorbtion nd therefore increase excretion oof G in urine, hence plasma concentrations of G are reduced

Question 4

Target of a-glycoidase inhibitors

Answer 4

A-glucosidase (maltase)

Question 5

What is a-glucosidase

Answer 5

Enzyme that breaks down short chin oligosacchrides including maltose to G in the GIT

Question 6

When is a-glucosidase required

Answer 6

Before G can be absorbed from gut into the bloodstream

Question 7

Acarbose

Answer 7

Inhibits a-glucosidase thus reducing G absorb nd reducing post prandial G conc