Premedication Flashcards
Sedation
indiction of CNS deression and drowsiness by use of drugs
tranquilization
used somewhat synonymously to sedation
analgesia
aka antinociception
loss or reduction or pain sensation
general anesthesia
controlled and reversible loss of consciousness, nociception and mobility
balanced anesthesia
using multiple drugs to achieve the goals of general anesthesia with less side effects than using a single agent
dissociative anesthesia
a form of general anestheisa characterized by a catatonic state; dissociate the different parts of the brain - neural informaton is processed without proper coordination in space and time
e.g Katamine
neuroleptanalgesia
state similar to general anesthesia produced by a sedative and an analgesic agent
e.g. phenothiazine + opioid
inhalation anesthesia
general anesthesia using inhalational drugs
e.g Isoflurane, Sevoflurane
Total Intravenous Anesthesia (TIVA)
achieved soley by injectable drugs
e.g. propfol, opioids
Partial Intravenous Anesthesia
combination of injectable drugs and lower concentration of inhaled anesthetic agent
local anesthesia
loss of sensation in a smaller, circumscribed body area
e.g infiltration, small nerve blocks
regional anesthesia
loss of sensation in a larger but limited body area
parts of the anesthetic procedure
premedication
induction
maintenance
recovery
list 2 anticholinergics that can be used as a premed
atropine
glycopyrrolate
Main indications for anticholinergics
Bradycardia
when are anticholinergics contraindicated
tachycardia
hyperthyroidism (almost the same as tachycardia)
most heart diseases
narrow angle glaucoma
CV side effect of anticholinergics
2º AV block, bradycardia, cardiac arrest
tachycardia, hypertension
what should atropine (anticholinergics) not be given with
alpha 2 agonist (metetomidine)
can result in vasocontriction, tachycardia, hypertension
how should bradycardia be treated
is there even a problem - consider species, age and Dz of patient
drugs: atropine, atipamezole (alpha 2 antagonist)
T/F anticholinergics may cause intestinal paralysis leading to colic in horses
True
should you give atropine to rabbits
No
have high levels ofatropinase enzyme - broken down quickly and not effective
glycopyrrolate is the preferred anticholinergic
what are the strongest available sedatives
alpha 2 agonists
location of alpha 2 adrenergic receptors
presynaptic memebrane (CNS)
post-synaptic membrane (vascular smooth muscle)
extra-synaptic sites (pancreas, adipocytes)
how do alpha 2 agonist work
supression of NE release by negative feedback
T/F both alpha 1 and 2 mediate vasoconstriction
True
receptors located in the walls of arteries and veins
T/F one side effect of alpha 2 agonists is hyperglycemia
True
inhibit insulin release from beta cells in the pancreas
CNS effects of alpha 2
strong sedation (except pigs)
some analgesic effect
muscle relaxation
alpha 2 agonist CV effects
strong vasocontriction
reflex bradycardia
results in: low CO and tissue perfusion
T/F you can use atropine to reverse some of the effects of alpha 2 agonists
FALSE!!!
Don’t do this! use atipamezole instead
respiratory effects of alpha 2 agonists
mild respiratory depression