Blood Loss and Transfusion Flashcards

1
Q

what is a blood transfusion?

A

process of transferring blood or blood-based products from one individual into the circulatory system of another individual of same species

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2
Q

what is the purpose of transfusion

A

increase Hb content of blood

increase circulating volume

increase plasma albumin content

provide coagulation factors

provide functional platelets

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3
Q

T/F loss of 50% of circulating volume is fatal but the loss of 50% of hemoglobin may not be

A

True

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4
Q

types of blood products

A

fresh whole blood (PCV ~40%)

packed red cells (PCV ~70%)

fresh frozen plasma

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5
Q

when should fresh whole blood be used

A

increase Hb content

acute blood loss and if TP <3.5

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6
Q

when should packed red cells

A

increase Hb content

if TP > 3.5 g/dL

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7
Q

transfusion trigger values

A

acute blood loss >20% of blood volume

acute anemia: PCV <20%

chronic anemia: PCV <15%

anemia + anesthesia: PCV <20%

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8
Q

T/F clinical signs are more important than arbitrary trigger values

A

True

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9
Q

clinical signs of blood loss

A

pale mm

elevated heart rate

low blood pressue

weak pulse

blood in surgical sponges and suction container

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10
Q

T/F acute blood loss may not chamge PCV and TP

A

True

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11
Q

equation for estimating blood loss

A

blood loss (ml) = (PCV of suctioned fluid X vol. in canister (ml))/ preoperative patient PCV

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12
Q

how much blood can a standar surgical sponge contain

A

5 ml

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13
Q

how much blood should be given in acute blood loss

A

same amount as lost amount

general rule: 2ml whole blood/kg BW raises PCV by 1% (assuming donor PCV of 40%)

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14
Q

equation for amount of bloof to be transfused

A

blood to be transfused (ml) = ([PCV required - PCV recipient] x blood volume of recipient (ml)) / PCV of donor

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15
Q

what is the empurical dose for dogs and cats

A

10-40 mL/kg for dogs

5-20 mL/kg for cats

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16
Q

what is the dosing and rate for transfusions

A

start with 0.25 ml/kg for first 30min to test for rxn

continue with rate: 5-10 mL/kg/h; faster in emergency

complete transfusion within 4 hours

17
Q

T/F transfusions should not be mixed with ringers

A

True

Ca: blood will clot again

18
Q

T/F FFP is and effective method of increasing plasma albumin content

A

False

need large volumes for long hours

consider supplementation with concetrated albumin

19
Q

what is the best option for providing coagulation factors

A

cryoprecipitate

20
Q

T/F plasma (fresh or fresh frozen) may trigger allergc reaction

A

True

trigger immunity against blood group Ag-s (typing is necessary)

21
Q

what should be given to provide functional platelets

A

fresh whole blood

plastic container - platelets adhere to glass

transfuse within 8 hours

store at room temp

22
Q

T/F platelet rich plasma is better than fresh whole blood for replacing platelets but difficult to get in vet med

A

true

23
Q

donor selection parameters

A

free from blood born disease

actual vaccination status

good general physical condition

not too young or too old

middle to large body size

preferable castrated male of nulliparous female

24
Q

when collecting blood in an open system it should be used within…

A

12 hours

25
Q

types of anticoagulants used

A

CPD

Na citrate

heparin

26
Q

side effects of transfusions

A

circulatory overload

transfusion related acute lung injury (TRALI)

citrate induced hypoCa (tetany)

sepsis

transmission of infectious diseases

27
Q

T/F long term benefits of transfusions are questionable and should only be done when absolutely necessary to save a life

A

True

28
Q

acute reaction from blood type incompatibility

A

life threatening

hemolysis (horses and cattle)

agglutination

29
Q

blood typing incompatability - slow reaction

A

decreased life span of RBC (few days)

30
Q

signs of acute reactions

A

increased HR and RR, decreased BP, dyspnea

wheals, urticaria, fever

pain at injection site

CV collapse, hemolysis, renal failure, DIC

less signs under anesthesia

31
Q

tx of acute rxn

A

stop transfusion

epi IV

antihistamines IV

32
Q

equine blood groups

A

type Aa and Qa - most antigenic

typing difficult, cross matching not reliable

no naturally occuring antibodies

33
Q

what is cross matching

A

determines serological compatibility between recpient and donor

based on agglutination reaction

34
Q

major cross match

A

donor RBCs + recpient plasma

35
Q

minor cross match

A

recpient RBC + donor plasma

36
Q

what is oxyglobin

A

stabilized bovine hemoglobin

used in tx of anemia in dogs

duration of effect - min 24 hours

may cause circulatory overload