Non-Steroidal Anti-Inflammatory Drugs Flashcards
clinical uses of NSAIDs
mild to moderate post OP pain or chronic pain
may be better than opioids for inflammatory pain
PG derivatives and leukotrienes are
inflammatory mediators - have role in developement of pain
COX and LOX inhibition
reduces the amount of synthesized inflammatory mediators
induces analgesia
COX -1
constantly synthesized
important for normal function of: GI, platelets, kidneys
COX - 2
inducible (not sunthesized constantly)
produced in response to inflammation - leads to the developement of pain
T/F COX - 2enzyme may also be constituative
true
the inhibition of _____ may increase _____ activity
the inhibition of COX may increase LOX activity
what is the largest group of veterinary drugs having adverse effects reported by the FDA
NSAIDs
main side effects of NSAIDs
GI - ulceration, perforation, V+, D+
hemostatic abnormality - inhibition of platelet fxn
renal imparement
hepatotoxic
impairment of cartilage synthesis
mechanism of renal damage
impair the defense mechanism of the kidneys in the face of hypotension - PGs mediate dilation of renal afferent arteries (keep GFR up)
why do most clinicians agree its safer to give NSAIDs right before the end of Sx/ during recovery
concern of hypotension, hypovolemia (bleeding) developing during op→renal damage
contraindications of NSAIDs
hypovolemia, hypotension
organ diseases
hemostatic abnormality
pregnancy/lactation - keep ductus arteriosus open
very young or very old
concomitant glucocorticoid therapy
indications of chronic therapy
arthritis, cystitis, dermatitis, gingervitis, cancer
which NSAID can be used for chronic therapy in cats
meloxicam
when should owner stop NSAID therapy and consult a vet
if animal stops eating or drinking
