Inhalants Anesthesia Flashcards
why use inhalant anesthesia
predictable effects (narcosis, muscle relaxation, not analgesic)
rapid adjustment of depth
minimal metabolism
economical
vapor
gaseous state of a substance that is a liquid at ambient temp and pressure
gas
exists in gaseous state a ambient temp and pressure
N2O
low blood gas PC
mild analgesic
acumulates in clased gas spaces
Xenon
expensive
mostly experimental at this time
Dalton’s Law of partial pressure
total pressure of a gas mixture is equal to the sum of the partial pressure of the individual gases
vapor pressure
pressure exerted by vapor molecules when liquid and vapor phases are in equilibrium
vapor pressure is dependent on…
temperature
increases with increasing temp; inversely related to boiling point
T/F desflurane is maintained in the gaseous form
True
blends with O2 to acheive vaporizer setting
saturated vapor pressure
maximum administration percentage
T/F vaporizers are needed to reduce the saturated vapor pressure to clinically useful doses
True
anesthetic vapors dissove in
liquids and solids
when is equalibrium reached
when the partial pressure of the anesthetic is the same in each phase
(partial pressure equal, but number of anesthetic molecules are not)
what is solubility expressed as
partition coefficient
what is the partition coefficient
concentration ratio of an anesthetic in the solvent and gas phase
describes the capacity of a given solvent to dissolve the anesthetic gas
what is the most clinically useful number
blood gas partition coefficient
what is the blood-gas partition coefficient
amount of an anesthetic in the blood vs. alveolar gas at equal partial pressures
the anesthetic in alveolar gas represents…
brain concentration
this is the location of effect
anesthetic dissolved in the blood is ppharmacologically…
Inactive
low blood gas PC
less anesthetic dissolved in blood at equal patial pressure
(more in alveoli)
short induction and recovery - more clinically useful
high blood gas PC
more anesthetic dissolved in blood at equal partial pressure
(less in alveoli)
long induction and recover
the partial pressure in the brain is equal to
partial pressure in the aveoli
how can PA be increased
increase the anesthetic delivery to alveoli
decrease removal from alveoli
how can PI be increased
increase vaporizer setting
increase fresh gas flow
decrease breathing cicuit
decrease removal from alveoli by
decrease blood solubilty of anethetic
decrease CO - patients with low CO will have a faster rse of PA
decrease alveolar-venous anesthetic gradient
T/F the higher the PI the more rapidly PA approaches PI
True