Neuromuscular Blocking Drugs Flashcards
what are Neuromuscular Blocking Drugs
interrupt transmission of nerve impulses at the neuromuscular junction
what do NMBDs result in
paralysis of striated muscle
consciousness is retained
no analgesia
spontaneous respiration ceases
indications for NMBD
position eyeball centrally - intraocular or corneal surgeries, most common
relax resiratory muscles to allow mechanical ventilation - rare
relax muscles for neurological or orthopedic surgeries - rare
T/F mechanical ventilation required with NMBD
true
they wont breathe
what is the only sign they will show in response to noxious stimuli
tachycardia
high blood pressure
what are some contraindications of NMBDs
no possibility to ventiate and monitor
if animals remain conscous - extremely distressing even without pain
insufficient analgesia during surgery
T/F NMDBs must not be used as a sole agent for any kind of procedure (painful or non painful)
True!!
depolarizing NMBDs
agonist on the nicotinic ACh receptors
cause muscle membrane depolarization
non-depolarizing NMBDs
antagonist on the nicotinic ACh receptors
stabilizes muscle membranes
which muscles are the most senesitive and be paralyzed first even at low doses
ocular muscles
which muscles are the most resistant and are last to paralyze and first to recover
diaphragm
which drugs potentiate NMBD effect
inhalational anesthetics
facots that influence the depth of NMBD effect
hypothermia
electrolyte abnormalities
age
NMBDs are water/lipid soluble
water
dont cross lipid barriers easily
which NMBD is most likely to cause histamine release
Atracurcium
