Physiology Flashcards
Term for EE above resting rate post exercise?
EPOC/Excess post-exercise oxygen consumption
What is relative VO2max?
Total volume of oxygen consumed related to body weight (in kg)
Formula for calculating VO2max?
Relative VO2max = L/min x 1000 divided by body weight
Why is it important to measure EE?
Your diet revolves around the things you do everyday
Why is it good to eat a decent amount of carbs and protein post-workout?
Stimulates MPS, improves recovery and enhances the quality of the next workout
Minutes of aerobic activity recommended per week for 18-65 year olds?
150 mins moderate/75 mins vigorous/equivalent combinations of both
Formula for calculating respiratory exchange ratio?
RER = VCO2 produced divided by VO2 consumed
Oxygen (L/min) needed per min to satisfy resting energy requirements?
0.2-0.35 L/min
Formula for calculating METs?
METs x 3.5 x Body Weight (kg) divided by 200 = kcal/min
What is the equivalent of foodstuff + oxygen?
Water + CO2 + ATP + Heat
What units can energy be reported in?
Joule (J) & kilocalorie (kcal)
What are the main purposes of energy?
Growth, repair, digestion, and storage
What is the 1st law of thermodynamics?
Energy can be changed from one form to another, but it cannot be created or destroyed
What is 1kcal in Joules?
4186J
What is the ratio of CO2 expired to O2 consumed at the level of lungs?
The respiratory exchange ratio
What is the average total metabolic rate of an individual engaged in normal daily activities?
1800-3000kcal
What is direct calorimetry?
The measurement of heat production from an individual, in calories, when placed in an insulated chamber.
Where does direct calorimetry usually take place?
In a professional medical setting and on a treadmill.
How is the volume of oxygen consumed measured in direct calorimetry?
Measured through the exhaled air.
How is heat production measured in direct calorimetry?
The temperature of water (which travels through the room via pipes) is measured before and after the subject enters the room.
What are the limitations of direct calorimetry?
- A small percentage of heat will be lost by friction
- A small percentage of heat will still be stored in sweat molecules
- The method wouldn’t be relevant to measuring EE of stop/start sports
What is indirect calorimetry?
The method by which measurements of the RER are used to estimate the EE.
What is the principle of indirect calorimetry?
Energy releasing reactions in the body depend upon oxygen utilised and carbon dioxide produced.
What is the assumption of indirect calorimetry?
Rate of oxygen and carbon dioxide exchanged in the lungs = Rate of usage and release by body tissues.
What is an example of indirect calorimetry?
Spirometry
What is closed circuit spirometry?
- ) Subject inhales via a face mask from a container full of oxygen.
- ) Exhaled air goes back to the container via soda lime, which absorbs CO2.
- ) This changes the volume of oxygen in the container and is recorded as volume of oxygen consumed.
Equipment for open circuit spirometry?
- Treadmill
- Low resistance 2 way valve
- A nose clip
- Low resistance falconia tubing
- Douglas bag
What is meant to occur in open circuit spirometry?
- Exhaled oxygen = decrease
- CO2 = increase
- Nitrogen = stays at a similar percentage compared to inhalation
Why isn’t all oxygen used up in spirometry or exercise?
Oxygen still provides for other bodily functions, such as the function of your organs, and cannot all be used for exercise
What is the oxygen consumption formula? Units?
Volume of oxygen in - Volume of oxygen out = Oxygen consumption (VO2) (L/min)
What is VO2? VCO2?
VO2 = Oxygen consumption VCO2 = Carbon dioxide output
Other terms/abbreviations for carbohydrates?
- CHO
- Glucose
What factors influence energy expenditure?
- Gender
- Age
- Body mass
What is ATP?
- Adenosine Triphosphate
- Important to all life as it stores and releases energy for many cellular processes
What does a fixed amount of energy expenditure always produce?
A fixed amount of heat
Ways of measuring energy expenditure?
- Amount of movement
- Weight gain/loss
- Calorimetry
Source of recommended activity guidelines? Year?
Gary O’Donovan, Journal of Sport Sciences, 2010
What RER suggests that fat is the predominant source fuel? Carbs?
- Fat = 0.7
- Carbs = 1.0
What are the names of the key connective tissue in muscle?
Epimysium Perimysium Fascicle Endomysium Muscle cell
What is epimysium?
The connective tissue around muscle
What is total muscle?
Groups of fascicles
What is perimysium?
The connective tissue around fascicles
What are fascicles?
Groups of muscle cells
What is endomysium?
The connective tissue around muscle cells
What are muscle cells?
The cells that make up muscle
Easy sentence to remember the structure of muscle?
Even Pulis Finds Emery Mad
3 key features of skeletal muscle?
- ) Movement of skeleton
- ) Under voluntary control
- ) Rapid and forceful contractions for short durations
What is a sarcomere?
The functional unit of striated muscle (the most basic unit that makes up our skeletal muscle).
How many different parts does the sarcomere have? Names?
5 parts:
- ) A Line
- ) H Line
- ) I Line
- ) M Line
- ) Z Disc
Easy sentence to remember the structure of a sarcomere?
I must have a zebra
What is the A Line in a sarcomere?
Thick filaments (myosin) length
What is the H Line in a sarcomere?
Thick filaments (myosin) but no thin filaments (actin)
What is the I Line in a sarcomere?
Thin filaments (actin) but no thick filaments (myosin)
What is the M Line in a sarcomere?
Supporting proteins holding the thick filaments (myosin) in place
What are Z Disc’s?
Defines the boundaries of an individual sarcomere
What are the 5 key ingredients required for muscle contraction?
- ) Action potential
- ) Calcium
- ) ATP
- ) Actin
- ) Myosin
First step of the sliding filament theory?
Action potential causes the release of calcium from the sarcoplasmic reticulum.
Where is calcium stored?
In the sarcoplasmic reticulum
Chemical name/abbreviation for calcium?
Ca2+
Chemical name/abbreviation for inorganic phosphate?
Pi
What is troponin?
Protein in muscle fibres that help to regulate muscle contraction.
What is actin?
The thin filaments in a sarcomere
What is myosin?
The thick filaments in a sarcomere
4 key steps for initiating a contraction?
- ) A stimulus to the skin is received by a sensory receptor
- ) The action potential travels through sensory neurons to the CNS
- ) The CNS interprets the information and the most appropriate motor response is derived
- ) The motor action potential travels out from the CNS through motor neurons to the appropriate point
What are action potentials?
Nerve signals.
What is resting membrane potential?
The difference in sodium and potassium ions inside and outside a neuron (nerve cell) = -70mV (millivolts)
Chemical name/abbreviation for sodium?
Na+
Chemical name/abbreviation for potassium?
K+
Key parts of a neuron (nerve cell)?
- Cell Body
- Dendrites
- Axon
- Synaptic end bulb
How can you measure the voltage across a neuron (nerve cell)?
Using a voltmeter
What happens to a neuron (nerve cell) when a stimulus occurs?
- Sodium (Na+) moves into the cell and Potassium moves out
- Inside of the cell becomes less negative
What is depolarization?
When the inside of a neuron (nerve cell) becomes less negative due to a stimulus
What happens when you get a depolarization greater than or equal to 15-20 mV?
- Threshold occurs
- Action potential is generated
How is action potential generated?
- ) -70mV is the resting membrane potential
- ) If the stimulus is sufficient to cause a depolarization greater than or equal to 15-20 mV (e.g. membrane potential becomes -55mV to -50mV) threshold occurs
- ) Action potential is generated
How does depolarization occur?
- ) Voltage gated sodium channels open after a stimulus
- ) Rapid sodium entry into the neuron occurs, making the inside less negative
- ) Voltage gated potassium channels open
- ) Potassium leaves the neuron to the outside extra cellular fluid
What are voltage gated sodium/potassium/calcium channels?
Small compartments on the membrane of a neuron (nerve cell) which allow the movement of sodium/potassium/calcium in/out of the cell
What occurs after depolarization in a neuron (nerve cell)?
- ) Voltage gated potassium channels remain open after depolarization allowing additional potassium to leave the neuron (nerve cell) = hyperpolarization
- ) Eventually the channels close
- ) Less potassium leaves the cell
- ) Sodium is pumped out of the cell
- ) Cell returns to its resting membrane potential
What is hyperpolarization?
When additional potassium leaves a neuron (nerve cell) due to the voltage gated potassium channels remaining open after depolarization
Where does action potential move to and from along a nerve cell?
Axon hillock to the axon terminal
What is the term for the process of a substance being produced and discharged by a cell?
Secretion
What is the term for the process of action potential moving from one node of ranvier to the next?
Saltatory conduction
What separates each node of ranvier along a neuron (nerve cell)?
Myelin sheath
What is the myelin sheath?
A waxy substance secreted by the schwaan cell that separates the nodes of ranvier
What are the nodes of ranvier?
The regions of the cell where there is no myelin sheath
What is the schwaan cell?
A cell that secretes myelin sheath
How does action potential move along a neuron (nerve cell)?
- Opening of the voltage gated sodium channels
- Action potential develops as an electrical impulse
- Action potential jumps from one node of ranvier to the next
Where does action potential specifically move to and from when moving from nerve to muscle?
From the cell body to the motor end plate
Where does the nerve cell come into very close contact with the muscle cell?
Motor end plate
What happens when action potential as an electrical impulse reaches the motor end plate?
- Voltage gated calcium channels open
- Calcium moves into the cell
What happens when calcium moves into the neuron (nerve cell)?
- ) Vesicles containing acetylcholine fuse with the end of the nerve cell
- ) Acetylcholine releases into the gap between the nerve cell and muscle
- ) Acetylcholine attaches to the surface of the muscle cell
What happens when acetylcholine attaches to the surface of the muscle cell?
- ) Causes gates on muscle cell to open and sodium rushes in
- ) AP then passes through the muscle cell and calcium is released from the sarcoplasmic reticulum
What happens when AP passes through the muscle cell and calcium is released from the sarcoplasmic reticulum?
- ) Causes a change in actin allowing binding to occur
2. ) Allows the sliding filament theory to occur thus leading to muscle contraction
What is a neurotransmitter?
A group of chemical substances released by neurons to stimulate other neurons or muscle or gland cells
How fast does action potential travel through a neuron (nerve cell)?
119m/s
What is multiple sclerosis?
- Autoimmune disease that attacks myelin sheath causing scarring
- This results in the slowing/blocking of action potential
What is demyelination?
Any condition that attacks myelin
What is sclerosis?
When the myelin sheath is scarred
What is a muscle biopsy?
- A method of examining an individuals fibre types
1. ) A small device plunged into muscle, removing a sample of it
2. ) It is then frozen, sliced up, stained, and looked at under a microscope
3. ) Type 1 appears black, type 2a = white, type 2x = grey
What are type 1 muscle fibres?
Slow twitch muscle fibres
What are type 2 muscle fibres?
Fast twitch muscle fibres
What determines fibre type?
Fibre type depends upon the nerve (motor) that innervates the fibres
What are the characteristics of type 1 fibres?
- High oxidative capacity
- Low glycolytic capacity
- Slow contractile speed
- High fatigue resistance
- Low motor unit strength
What are the characteristics of type 2 (x) fibres?
- Low oxidative capacity
- Highest glycolytic capacity
- Fast contractile speed
- Low fatigue resistance
- High motor unit strength
What is a motor unit?
Term to describe a group of muscle fibres controlled by a single nerve
Which fibre type means that the motor nerve fires at a low frequency?
Slow twitch/type 1
Which fibre type means that the motor nerve fires at a high frequency?
Fast twitch/type 2
Why is power greater in type 2 muscle fibres for the same absolute force?
- ) Velocity is 5-6 times greater
- ) Fast form of myosin ATPase, therefore faster cross bridges are formed
- ) More developed SR, therefore greater storage of calcium and a faster release of it
Formula for power?
Power = Force x Velocity
What is myosin ATPase?
The enzyme that helps break down ATP in the myosin head
What are enzymes?
Proteins that speeds up the rate of a chemical reaction in a living organisms
Why is force 10-20% greater in type 2 fibres?
- ) Larger, therefore more myosin cross-bridges per unit CSA
- ) Motor nerve excite >300 fibres whereas type 1 = <300
CSA?
Cross sectional area
What does the level of force a muscle produces depend upon?
- ) Number and type of motor units recruited
- ) Firing frequency of each motor unit
- ) The size of muscle
- ) Speed and type of contraction
- ) Sarcomere length
Why is there an optimal sarcomere length for force production? (Person and year?)
There is an optimal overlap between thick (myosin) and thin (actin) filaments. (Macintosh, 2006)
When do we get maximum force?
When there is maximum cross-bridge formation being able to generate force
When does maximal isometric force occur?
At zero velocity
What happens as the velocity of concentric contraction increases?
Force generation decreases
What is a reason for force generation decreasing as the velocity of contraction increases?
As the velocity is increasing, there is insufficient time for myosin and actin to form cross bridges during force
What happens as the velocity of eccentric contraction increases?
Force generation increases
What is a reason for force generation increasing as eccentric contraction increases?
Increased number of cross bridges attached to actin, increased actin/myosin interactions generating more force
In what way are muscle fibres recruited?
During a physical task according to their size, in this order:
- ) Type 1/Slow twitch
- ) Type IIa
- ) Type IIx
In what pattern does the blood flow through the heart?
Cycle of down, up, down, up
How does deoxygenated blood travel DOWN the heart?
- ) Superior vena cava
- ) Right atrium
- ) Tricuspid valve
- ) Right ventricle
How does deoxygenated blood travel UP the heart?
- ) Pulmonary semilunar valve
2. ) Pulmonary artery
What does blood do after it travels through the left pulmonary artery?
Picks up oxygen from the lungs
How does oxygenated blood travel DOWN the heart?
- ) Pulmonary vein
- ) Left atrium
- ) Mitral (biscupid) valve
- ) Left ventricle
How does oxygenated blood travel UP the heart prior to around the body and before the cycle repeats itself?
- ) Aortic semi-lunar valve
2. ) Aorta
What is the whole heart known as? What does it mean?
Myocardium:
- Myo = muscle
- Cardium = heart
Which part of the myocardium divides the two ventricles?
Interventricular septum
Cardiac structure? (outside to inside)
- ) Fibrous pericardium
- ) Pericardium
- ) Pericardial cavity
- ) Epicardium
- ) Myocardium
- ) Endocardium
- ) Heart chamber
What is the role of the pericardial cavity?
To allow the expansion and contraction of the heart
3 layers of the heart which classify as the ‘heart wall’?
- ) Epicardium
- ) Myocardium
- ) Endocardium
How does blood travel AWAY from the heart?
Through the pulmonary artery
How does blood travel TOWARDS the heart?
Through the pulmonary vein
What is the biggest chamber of the heart?
Left ventricle
When does the first heart sound occur?
When the atrioventricular valves close and the semilunar valves open
When does the second heart sound occur?
When the semilunar valves close and the semilunar valves open
What does systole mean?
Contraction of`
When is the atria relaxed?
During the ventricular systole & diastole phase
What does diastole mean?
Relaxation of
What happens during phase 1 of the Wiggins diagram?
Rapid ventricular filling:
- Mitral valve opens
- Zero aortic blood flow
What happens during phase 2 of the Wiggins diagram?
Rapid ventricular filling begins to slow down:
- Mitral valve still open
- Still zero aortic blood flow
What happens during phase 3 of the Wiggins diagram?
Atrial systole occurs:
- Still zero aortic blood flow
- Ventricles are full of blood and pressure starts to build
What happens during isovolumetric contraction? (Phase 4 of Wiggins diagram during ventricular systole)
- ) Mitral valve closes and ventricular pressure increases as its full of blood
- ) Aortic valve opens
What happens during rapid ejection? (Phase 5 of Wiggins diagram during ventricular systole)
Blood flows out at a high pressure thus ventricular volume decreases and aortic blood flow increases
Another term for aortic blood flow?
Ventricular outflow
What happens during reduced ejection? (Phase 6 of Wiggins diagram during ventricular systole)
- Blood is released at a reduced rate
- Left ventricular pressure decreases
- Aortic blood flow decreases
What happens during isovolumetric relaxation? (Phase 7 of Wiggins diagram during ventricular systole) (Final phase)
- Left ventricular pressure continues to decrease
- Aortic blood flow returns to zero as the aortic valve closes
- Ventricular volume plateaus
2 key terms for intrinsic cardiac stimulation?
- ) Autorhythmic
2. ) Myogenic
What does Autorhythmic refer to?
The heart maintains its own pulse rate.
- External control dictates the change in pulse rate
- Without external stimulus pulse rate would be 100bpm
What does Myogenic refer to?
The heart acts as its own conduction system as the cardiac cells are able to conduct electrical stimulation, and activate the cardiac muscle cells in a particular pathway
How is the heart Autorhythmic?
- ) The sinoatrial node, located at the top right atria stimulates the atria and makes it contract.
- ) It then sends a signal to the atrioventricular node, located between the aria and ventricles in the middle of the heart.
- ) The atrioventricular node then sends an electrical impulse around the ventricles initiating their contraction, sending blood through the body.
2 types of extrinsic cardiac control?
- ) Parasympathetic
2. ) Sympathetic
What is the role of the parasympathetic nervous system?
The slowing of the heart, hyperpolarising autorhythmic fibres.
What is the vagus nerve?
Part of the PNS.
Decreases heart rate and force of contraction.
What does PNS mean?
Parasympathetic nervous system.
What does SNS mean?
Sympathetic nervous system.
What is the role of the sympathetic nervous system?
To increase HR and force of contraction due to a stress stimulus, through depolarising autorhythmic fibres.
How does the SNS increase BPM?
Uses either:
The sympathetic cardiac nerve to act on the SA node or the AV node.
Through catecholamines.
What are cathecholamines?
Adrenaline.
What does ‘hyperpolarisation’ mean?
A less polarised state making it harder for a contraction to occur
What does ‘depolarisation’ mean?
A more polarised state making it easier for a contraction to occur.
What type of control is the heart under when your HR is BELOW 100bpm? Through what?
Under parasympathetic control through the vagus nerve
What type of control is the heart under when you HR is OVER 100bpm? Through what?
Under sympathetic control through sympathetic fibres and cathecholamines
What does ‘polarisation’ refer to?
The level of charge a nerve fibre has.
What happens to nerves millivolts when depolarisation occurs?
The level of charge goes closer to zero from -70mv.
What happens to nerves millivolts when repolarisation occurs?
The level of charge increases/decreases AWAY from zero.
What happens to nerves millivolts when hyperpolarization occurs?
Decreasing level of charge.
Hyperplasia?
An increase in the number of cells within a muscle associated with maturation.
Statural/incremental growth?
Body mass increases in size and length.
What is statural/incremental growth due to?
An increase in the length of bones.
Where do the cells involving growth habituate?
Epiphyseal plate.
When does growth stop?
When your epiphyseal plates fuse and create solid bone.
3 types of growth?
- ) Statural/incremental growth.
- ) Hypertrophic growth.
- ) Reparative growth.
Hypertrophic growth?
Body mass increases in response to functional demands.
Reparative growth?
Structural maintenance of tissue and repair of damaged tissues.
3 stages of growth & development?
- ) Infancy.
- ) Childhood.
- ) Adolescence.
When does a very rapid rate of growth and improved neuromuscular co-ordination occur?
During infancy.
How long does the infancy period last for?
1 year.
When does a steady rate of growth and maturation with large increases in motor co-ordination occur?
Childhood.
When is the childhood period?
Junior school years.
When does the growth spurt and puberty phase occur?
During adolescence.
Until around what age do boys and girls grow at a similar rate?
8.
When does peak height velocity occur in girls?
8-12 years.
When does peak height velocity occur for boys?
12-15 years.
What factors regulate growth?
Hormones.
Environmental factors.
What does the growth hormone affect the most?
Long bones.
Which hormone tends to turn off the epiphyseal plates causing bones to fuse?
Oestrogen.
Do men or women produce more oestrogen?
Women.
What environmental factors up regulate GH, receptors and stimulate growth factors?
Moderate exercise.
Proper nutrition.
What environmental factors can impair growth?
Excessive exercise.
Inadequate caloric intake.
Maturation?
The timing and tempo of the biological system as it matures.
What is the final period in the growth process leading to maturity?
Adolescence.
When does adolescence begin?
When you reach critical levels of: Body fat. Body mass. Height. Skeletal maturity.
When does adolescence occur for girls on average? Boys?
Girls = 10.5-13 years. Boys = 12.5-15 years.
What happens to girls the earlier the onset of adolescence?
Rate of growth is faster the earlier the onset of adolescence.
What do female early maturers typically have?
Shorter legs.
Narrower shoulders.
What is the typical growth (inches) for girls per year during adolescence?
3 inches per year.
What do male early maturers typically have?
Muscular short legs.
Broader hips.
What is the typical growth (inches) for boys per year during adolescence?
4 inches per year.
What is considered a poor measure of “real” biological age?
Chronological age.
Most exercise performance indices are related to growth and maturation factors such as…?
Muscle mass.
Height.
Heart size.
Etc.
What types of body composition does maturation affect?
Fat tissue.
Bones.
Muscle.
How does hypertrophy/hyperplasia affect fat tissue throughout maturation?
Hypertrophy = Increase in fat cell size. Hyperplasia = Increase in fat cell number.
How does bone growth occur during maturation?
Deposition/increase of minerals.
Increasing number of cells.
How does muscle growth occur during maturation?
Hypertrophy.
Around what kg of fat free mass do boys/girls reach by adulthood?
Boys = 65kg. Girls = 45kg.
Around what kg of fat mass do boys/girls reach by adulthood?
Boys = 10kg. Girls = 15kg.
Around what fat % do boys/girls reach by adulthood?
Boys = 15%. Girls = 25%.
What factors in children warrant special consideration in exercise testing and prescription?
Smaller stature.
Smaller body mass.
Immaturity of their physiologic systems.
At the ages of 5, 7, 9 and 11, what excess % of energy will children need in order to walk at the same speed as an adult?
5 = 37% 7 = 26% 9 = 19% 11 = 13%
Gait dynamics?
The way you walk.
Second step of the sliding filament theory?
Calcium binds to troponin, moves tropomyosin and reveals binding site on actin.
Third step of the sliding filament theory?
Myosin attaches to actin via cross-bridge and power stroke occurs due to the release of inorganic phosphate.
Myofibrillar ATPase?
Identifying fast and slow contracting muscle fibres.
Cross-bridge cycling?
Bridges constantly being formed and broken during muscle contraction.