Pharmacology- Pharmacology of drug treatment in liver disease Flashcards
hepatotoxic drugs
excessive paracetemol
alcohol
statins
metheotrexate
statins
chloropromazine (obstructive jaundice)
which drug when taken in excessive doses is oxidised to the toxic metabolite NAPBQI as usual conjugation pathways become overwhelmed
a.ibruprofen
b.paracetemol
c.opiods
d. statins
e.alcohol
b.paracetemol
ascites, encephalopathy, coagulopathy , hepatorenal syndrome and varices / portal hypertension indicate which condition
a.hepatitis
b.cirrhosis
c. jaundice
d.alcohol poisonng
b.cirrhosis
what system is used for scoring cirrhosis
a.QRISK 3
b. child turcotte pugh scoring system
c. glasgow scale
b. child turcotte pugh scoring system
5-6 points on the CTP scoring system for cirrhosis indicates which class?
a.A
b.B
c.C
a.A
7-9 points on the CTP scoring system for cirrhosis indicates which class?
a.A
b.B
c.C
b.B
10-15 points on the CTP scoring system for cirrhosis indicates which class?
a.A
b.B
c.C
c.c
sodium restriction, paracentesis, banano catheter and transjugular intrahepatic portosystemic shunt are non pharmalogical measure to reduce which symptom of cirrhosis
a. ascites
b.encephalopathy
c.portal hypertension
d.coagulopathy
e.hepatorenal syndrome
a. ascites
which diuretic for ascites blocks the aldosterone receptor in the distal tubule
a. spironolactone
b. furosemide
c. cimetidine
d.lactulose
a. spironolactone
which diuretic for ascites inhibits the Na/K/2cl carrier in the luminal membrane in the loop of henle
a. spironolactone
b. furosemide
c. cimetidine
d.lactulose
b. furosemide
loop diueretic
excess ammonia from bacteria in the GIT not being converted to urea by a cirrohtic liver and entering the systemic circulation leads to which symptom of cirrhosis
a.coagulopathy
b.jaundice
c.portal hypertension
d.ascites
e. hepatic encephalopathy
e. hepatic encephalopathy
/ due to excess GABA in the brain
which drug is given 2-3 times daily in hepatic encephalopathy to stimulate the passage of ammonia from tissues into the gut lumen and inhibit intestinal ammonia production
a. movicol
b.rifaximin
c.senna
d. thiamine
e. lactulose
e. lactulose
which drug is given as slow IV 30 mins 8 hrly for a few days then changed to oral supplements to treat malnutrition in hepatic encephalopathy
a. movicol
b.rifaximin
c.senna
d. thiamine
e. lactulose
d. thiamine
which drug is given to reduce frequency of encephalopathy episodes in hepatic encephalopathy
a. movicol
b.rifaximin
c.senna
d. thiamine
e. lactulose
b.rifaximin
coagulopathy is diagnised by..
a.increased prothrombin time
b.decreased thrombrombin time
a.increased prothrombin time
hat drug is used to treat coagulopathy in cirrhosis
a. vit k
b.rifaximin
c.senna
d. thiamine
e. lactulose
a. vit k
vit k dependent factors - II, vII, IX , X
sphlanchnic ……… is an issue in hepatorenal syndrome
a.vasoconstriction
b. vasodilation
b. vasodilation
which drug is used to treat hepatorenal syndrome in cirrhosis
a. vit k
b.rifaximin
c.vasopressin analogues
d. thiamine
e. lactulose
c.vasopressin analogues
what do liver function tests measure
a.serum levels of liver enzymes
b.stiffness of the liver
c. the rate at which the liver absorbs nutrients
d. the rate at which the liver detoxifies substances
a.serum levels of liver enzymes
also pt time and albumin
increased ALP and GGT indicate which type of jaundice
a.obstructive
b. hepatic
a.obstructive
increased AST and ALP indicate which type of jaundice
a.obstructive
b. hepatic
b. hepatic
which enzymes are responsible for the phase 1 reactions that use oxidation/ reduction/ hydrolysis to form more chemically reactive products allowing for wasy conjugation to make a more water soluble molecule in phase 2
a.cyp450
b. urease
c.camp
d.protein kinase a
a.cyp450
Which drugs increase the synthesis of or decrease the breakdown of cyp450
PC BRAGS
PC BRAGS
phenytoin
carbamaxepine/ cigs
barbituates
rifampicin
alcohol
glucocorticoifds
st johns wort
