Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GERR > Pharmacology - Drugs and the thyroid > Flashcards

Pharmacology - Drugs and the thyroid Flashcards

1
Q

what effect does excess iodide have on the thyroid gland

a.activation
b.inhibition

A

a.activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

where is the receptor for thyroid hormones found

a.cell membrane
b.cytoplasm

A

b.cytoplasm

binding to it opens up zinc finger domain and binds to hormone response element upstream from promoter region

effects functioning of RNA polymerase, gene transcription and mRNA translation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what effect does T3 have on basal metabolic rate

a.increase
b.decrease

A

a.increase

increases protein synthesis, oxygen consumption and heart rate

accelerator on car

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

nervousness , shakiness, palpatations , increased appetite and decreased weight are signs of …

a.thyrotoxicosis
b.hypothyroidism

A

a.thyrotoxicosis

can be either …
hyperthyroidism. - increased production
/ thyroiditis -increased secretion due to inflam of thyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

how is hyperthyroidism treated if there is tracheal compression

a.lifestyle
b.pharmacologically
c.surgically

A

c.surgically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

options for pharmacological treatment of hyperthyroidism

A

block
block and replace
radioactive iodine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

which drugs are given to block in hyperthyroidism

a.thioureylenes
b. thyroxine
c.Lugols iodine

A

a.thioureylenes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Carbimazole and propylthiouracil are examples of which type of drug used to block in hyperthyroidism

a.fluoroquinolines
b. thiourylenes
c. antibiotics
d.sglt2 inhibitors

A

b. thiourylenes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the mechanism of action of thioureylenes

A

inhibit iodination of tyr residues in thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

how are thioureylenes given

a.SC
b.IV
c.IM
d.orally

A

d.orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what type of reduction do thioureylenes have in signs and symptoms of hyperthyroidism

a.fast decrease
b.gradual decrease

A

b.gradual decrease

4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is given initially in hyperthyroidism

a.carbimazole
b.proplythiouracil
c.propanaolol
d.

A

c.propanaolol

rapid relief of symptoms given when starting initially with carbimazole

reduce carbimazole gradullay until at maintenance level for 12 months then discuss discontinuation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

if hyperthyroidism recurs following 12 months of carbimazole what is the next step

a.propylthiouracil
b.radioactive idoine
c.lugols iodine

A

b.radioactive idoine

or surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which side effect of thioureylenes are patients advised to seek care for urgently

a.rash

b.pruritus

c.agranulocytosis

d. nausea

A

c.agranulocytosis

if develop head cold or sore thorat immediately go to practice and get a full blood count

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what drug type is given as symptomatic relief in hyperhtyroidism

a.ace inhibitors
b.arbs
c. beta blockers
d.NSAIDS

A

c. beta blockers

also inhibits conversion of t3 to t4 in tissues
given orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

women taking thioureylenes should also be using ..

a.contraception
b. NSAIDs
c. vitamin supplements

A

a.contraception

cross [lacenta and cause goitre in baby

17
Q

what should be done if acute pancreatitis occurs on carbimazole

a.iv fluids given
b. stop immediately
c.gradually lower dose

A

b. stop immediately

18
Q

Block and replace should NEVER be given in which situtation

a. pre existing heart problems
b.elderly
c. pregnancy

A

c. pregnancy

19
Q

carbimazole is given with which other drug in block and replace therapy for hyperthyroidism

a.trimethoprim
b. levothyroxine
c.tyroxine
d. radioactive iodine

A

b. levothyroxine

again for 12 months

20
Q

radioactive iodine should be avoided in …

A

PREGNANCY

21
Q

following radioactive iodine (single dose orally) thyroid funciton tests sgould be done every 6 weeks for..

a. 6 months
b. 1 year
c. 2 years

A

a. 6 months

22
Q

what is first line treatment for suspicion of thyroid cancer

a. block
b. block and replace
c. radioactive iodine
d.total thyroidectomy

A

d.total thyroidectomy

23
Q

what is given post total thyroidectomy for the rest of the patients life

a. carbamizole
b. levothyroxine
c. trimethoprim
d. radioactive iodine

A

b. levothyroxine

and tft monitored every 6 weeks for 6 months

24
Q

feeling cold , tired, weight gain despite poor appetite , delayed reflexes and loss of hair especially outer 1/3 of eyebrow is associated with what condition

a.hyperthyroidism
b.thyroiditis
c. hypothyroidism

A

c. hypothyroidism

(pushing a brake on a car)

25
Q

what is given first line in hypothyroidism

a. carbimazole
b. levothyroxine
c. radioactive iodine

A

b. levothyroxine

introduce slowly increased every 4 weeks

GERR (53 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions