Pharmacology - Drugs and the thyroid Flashcards
what effect does excess iodide have on the thyroid gland
a.activation
b.inhibition
a.activation
where is the receptor for thyroid hormones found
a.cell membrane
b.cytoplasm
b.cytoplasm
binding to it opens up zinc finger domain and binds to hormone response element upstream from promoter region
effects functioning of RNA polymerase, gene transcription and mRNA translation
what effect does T3 have on basal metabolic rate
a.increase
b.decrease
a.increase
increases protein synthesis, oxygen consumption and heart rate
accelerator on car
nervousness , shakiness, palpatations , increased appetite and decreased weight are signs of …
a.thyrotoxicosis
b.hypothyroidism
a.thyrotoxicosis
can be either …
hyperthyroidism. - increased production
/ thyroiditis -increased secretion due to inflam of thyroid
how is hyperthyroidism treated if there is tracheal compression
a.lifestyle
b.pharmacologically
c.surgically
c.surgically
options for pharmacological treatment of hyperthyroidism
block
block and replace
radioactive iodine
which drugs are given to block in hyperthyroidism
a.thioureylenes
b. thyroxine
c.Lugols iodine
a.thioureylenes
Carbimazole and propylthiouracil are examples of which type of drug used to block in hyperthyroidism
a.fluoroquinolines
b. thiourylenes
c. antibiotics
d.sglt2 inhibitors
b. thiourylenes
what is the mechanism of action of thioureylenes
inhibit iodination of tyr residues in thyroglobulin
how are thioureylenes given
a.SC
b.IV
c.IM
d.orally
d.orally
what type of reduction do thioureylenes have in signs and symptoms of hyperthyroidism
a.fast decrease
b.gradual decrease
b.gradual decrease
4 weeks
what is given initially in hyperthyroidism
a.carbimazole
b.proplythiouracil
c.propanaolol
d.
c.propanaolol
rapid relief of symptoms given when starting initially with carbimazole
reduce carbimazole gradullay until at maintenance level for 12 months then discuss discontinuation
if hyperthyroidism recurs following 12 months of carbimazole what is the next step
a.propylthiouracil
b.radioactive idoine
c.lugols iodine
b.radioactive idoine
or surgery
which side effect of thioureylenes are patients advised to seek care for urgently
a.rash
b.pruritus
c.agranulocytosis
d. nausea
c.agranulocytosis
if develop head cold or sore thorat immediately go to practice and get a full blood count
what drug type is given as symptomatic relief in hyperhtyroidism
a.ace inhibitors
b.arbs
c. beta blockers
d.NSAIDS
c. beta blockers
also inhibits conversion of t3 to t4 in tissues
given orally
women taking thioureylenes should also be using ..
a.contraception
b. NSAIDs
c. vitamin supplements
a.contraception
cross [lacenta and cause goitre in baby
what should be done if acute pancreatitis occurs on carbimazole
a.iv fluids given
b. stop immediately
c.gradually lower dose
b. stop immediately
Block and replace should NEVER be given in which situtation
a. pre existing heart problems
b.elderly
c. pregnancy
c. pregnancy
carbimazole is given with which other drug in block and replace therapy for hyperthyroidism
a.trimethoprim
b. levothyroxine
c.tyroxine
d. radioactive iodine
b. levothyroxine
again for 12 months
radioactive iodine should be avoided in …
PREGNANCY
following radioactive iodine (single dose orally) thyroid funciton tests sgould be done every 6 weeks for..
a. 6 months
b. 1 year
c. 2 years
a. 6 months
what is first line treatment for suspicion of thyroid cancer
a. block
b. block and replace
c. radioactive iodine
d.total thyroidectomy
d.total thyroidectomy
what is given post total thyroidectomy for the rest of the patients life
a. carbamizole
b. levothyroxine
c. trimethoprim
d. radioactive iodine
b. levothyroxine
and tft monitored every 6 weeks for 6 months
feeling cold , tired, weight gain despite poor appetite , delayed reflexes and loss of hair especially outer 1/3 of eyebrow is associated with what condition
a.hyperthyroidism
b.thyroiditis
c. hypothyroidism
c. hypothyroidism
(pushing a brake on a car)
what is given first line in hypothyroidism
a. carbimazole
b. levothyroxine
c. radioactive iodine
b. levothyroxine
introduce slowly increased every 4 weeks
