Infection - Antibacterials Flashcards
which antibitoic categories inhibit cell wall synthesis
a.B lactams and glycopeptides
b.Tetracyclines, aminoglycosides,Macrolides,Lincosamides
c.Quinolones,folate synthesis inhibitors, Nitroimidazoles, rifamycins
a.B lactams and glycopeptides
what is the mode of action of B lactams and glycopeptides
a.inhibit cell wall synthesis
b. act on ribosome to inhibit protein synthesis
c.inhibit DNA/RNA synthesis
a.inhibit cell wall synthesis
what group of antibiotics do cephalosporins, carbapenems and monobactams belong to?
a.B lactams
b.glycopeptides
c.tetracyclines
d.macrolides
a.B lactams
what is the correct mode of action for B lactams eg penicillin, cephalosporins, carbapenems and monobactams
a.inhibit cross linking of the peptidoglycan chain leading to weakened bacterial cell walls and lysis
b.bind to amino acids in the peptidoglycan chain blocking addition of new units
c.act on the ribosome to inhibit protein synthesis
d.inhibit DNA/RNA synthesis
a.inhibit cross linking of the peptidoglycan chain leading to weakened bacterial cell walls and lysis
what is the correct mode of action for glycopeptides
a.inhibit cross linking of the peptidoglycan chain leading to weakened bacterial cell walls and lysis
b.bind to amino acids in the peptidoglycan chain blocking addition of new units
c.act on the ribosome to inhibit protein synthesis
d.inhibit DNA/RNA synthesis
b.bind to amino acids in the peptidoglycan chain blocking addition of new units
what is the correct mode of action for tetracyclines, macrolides, aminoglycosides, lincosamides
a.inhibit cross linking of the peptidoglycan chain leading to weakened bacterial cell walls and lysis
b.bind to amino acids in the peptidoglycan chain blocking addition of new units
c.act on the ribosome to inhibit protein synthesis
d.inhibit DNA/RNA synthesis
c.act on the ribosome to inhibit protein synthesis
what is the correct mode of action for rifamycins,quinolones ,nitroimidazoles and folate synthesis inhibitors
a.inhibit cross linking of the peptidoglycan chain leading to weakened bacterial cell walls and lysis
b.bind to amino acids in the peptidoglycan chain blocking addition of new units
c.act on the ribosome to inhibit protein synthesis
d.inhibit DNA/RNA synthesis
d.inhibit DNA/RNA synthesis
what type of antibiotic is ciprofloxacin
a.B lactam
b.glycopeptide
c.quinolones
d.nitromidazole
e.tetracycline
c.quinolones
what type of antibiotic is gentamicin
a.B lactam
b.aminoglycoside
c.quinolones
d.nitromidazole
e.tetracycline
b.aminoglycoside
what type of antibiotic is clarithromycin
a.B lactam
b.aminoglycoside
c.quinolones
d.macrolide
e.tetracycline
d.macrolide
what type of antibiotic is clindamycin
a.B lactam
b.aminoglycoside
c.lincosamide
d.macrolide
e.tetracycline
c.lincosamide
what type of antibiotic is trimepthoprim
a.B lactam
b.aminoglycoside
c.lincosamide
d.macrolide
e.folate synthesis inhibitor
e.folate synthesis inhibitor
what type of antibiotic is rifampcin
a.B lactam
b.aminoglycoside
c.lincosamide
d.rifamycin
e.folate synthesis inhibitor
d.rifamycin
what type of antibiotic is metronidazole
a.B lactam
b.aminoglycoside
c.nitroimidazole
d.rifamycin
e.folate synthesis inhibitor
c.nitroimidazole
which type of bacteria are resistant to glycopeptides as they cannot penetrate the outer membrane
a.gram positive
b.gram negative
b.gram negative
microbes lacking the target for a antibiotic is known as
a.intrinsic resistance
b.extrinsic resistance
c.acquired resistance
a.intrinsic resistance
microbes normally sensitive to a drug becoming resistant is known as
a.intrinsic resistance
b.extrinsic resistance
c.acquired resistance
c.acquired resistance
how does production of Beta lactamses allow for resistance to b lactam antibiotics
a.inactivate the antibiotic
b. modify the target site of the drug
c.modify the drug so it cannot bind
a.inactivate the antibiotic
how does production of Beta lactamses allow for resistance to b lactam antibiotics
a.inactivate the antibiotic
b. modify the target site of the drug
c.modify the drug so it cannot bind
a.inactivate the antibiotic
5 main mechanisms of antibiotic resistance
enzyme production
alteration of target sites
efflux pumps
alteration of outer membrane permeability
alteration of metabolic pathways
what is the main resistance type to tetracyclines
a.enzyme production
b.target site alteration
c.efflux pumps
d.alteration of outer membrane permeability
e.alteration of metabolic pathways
c.efflux pumps
bacteria acquire membrane channels that actively pump the antibiotic out of the cell
what is the main mechanism of resitance to B lactams in gram negative bacteria
a.enzyme production
b.target site alteration
c.outer membrane permeability alteration
d.efflux pumps
e.alteration to metabolic pathways
c.outer membrane permeability alteration
mutation in porin channel through which antibiotics enter the cell
reduced conc of antibiotic in the cell
in gram negatives
If suspected sepsis when should antibiotics be initiated
a.within and hour of diagnosis
b.within a day of diagnosis
c.within a week of diagnosis
a.within and hour of diagnosis
IV antibiotics
and take blood culture
which type of bacteria are the likely cause of cellulitis ?
a.gram positives
b.gram negatives
a.gram positives
staph aeureus and strep
which type of bacteria are the likely cause of a UTI
a.gram positive
b. gram negative
b. gram negative eg e coli
