Pharmacokinetics - Drug Metabolism and Excretion

Question 1

Which type of metabolism has greater saturability?

Answer 1

Phase II

Question 2

What two substrates are needed for phase I metabolism?

Answer 2

Molecular oxygen and NADPH

Question 3

Which type of metabolism is more inducible?

Answer 3

Phase I (alcoholics induce CYP2E1)

Question 4

Zero-order kinetics are displayed in reactions ______.

Answer 4

that react a constant amount per time (regardless of change in concentration).

Question 5

______ causes decreased clearance of Lipitor.

Answer 5

Erythromycin

Question 6

_______ is an enzyme inducer.

Answer 6

Phenobarbital

Question 7

Antifungal agents (drugs ending in -azole) are typically ______.

Answer 7

enzyme inhibitors

Question 8

Rifampin increases the clearance of _______.

Answer 8

oral contraceptives

Question 9

Early neonatal levels of ______ enzymes are 50% - 70% of adult levels.

Answer 9

phase I

Question 10

Warfarin targets ________.

Answer 10

vitamin K reductase

Question 11

Older people have decreased ______ metabolism.

Answer 11

phase I