Cell Growth and Neoplasia Flashcards

1
Q

Give an example of physiologic hypertrophy.

A

The uterus expanding during pregnancy

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2
Q

Give an example of pathologic hypertrophy.

A

The heart expanding during prolonged hypertension

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3
Q

______ is an example of physiologic hyperplasia.

A

Breast growth during puperty

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4
Q

In Barrett’s esophagus, normal ______ cells transition to ______ cells.

A

squamous; columnar (intestinal are higher risk than gastric)

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5
Q

Smokers often have a type of metaplasia in which _________.

A

normal, columnar bronchus cells transition to squamous cells

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6
Q

Although we often think of cell-autonomous factors with neoplasia, like ______, there are also extrinsic causes such as ______.

A

oncogenes and tumor suppressors; circulation of cytokines or changes in the micro-environment

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7
Q

List some features of benign neoplasms.

A

Well differentiated, low rate of cell turnover, cytologic uniformity, boundary between neoplasm and surrounding tissue, less necrosis.

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8
Q

List some features of malignant neoplasms.

A

Varying differentiation, high rate of turnover, cytologic polymorphism, less boundary between neoplasm and surrounding tissue, common necrosis.

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9
Q

Sarcomas are ______.

A

malignant tissues of mesenchymal origin (e.g., osteosarcoma, fibrosarcoma, chondrosarcoma)

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10
Q

Carcinomas are ________.

A

malignant neoplasms of epithelial origin (e.g., adenocarcinoma)

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11
Q

Adenomas are _________.

A

neoplasms of glandular tissue

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12
Q

Give some examples of benign neoplasias of mesenchymal origin.

A

Fibroma, osteoma, chondroma

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13
Q

Asbestos increases the incidence of _______.

A

mesothelioma in the lungs

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14
Q

Inflammatory bowel disease leads to a _______.

A

20-fold increase in the relative risk for colorectal cancer

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15
Q

List the six characteristic actions of cancer.

A

Evades apoptosis, sustains angiogenesis, invades tissue, is insensitive to anti-growth signals, has a limitless replication potential, and can self-signal for growth

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16
Q

Cancers of _____ tissue are most common.

A

epithelia (which are carcinomas)

17
Q

Dysplasia is _____.

A

disordered growth (as evinced by loss of cytologic uniformity, loss of cell architecture)

18
Q

Low-grade histologic indicates ______.

A

high degree of differentiation

19
Q

High-grade histology indicates _______.

A

low degree of differentiation (worse prognosis)

20
Q

Morphogenesis is another name for _______.

A

development