Pharmacokinetics - Drug Absorption

Question 1

List the four factors that affect drug absorption.

Answer 1

Molecular size; lipid solubility; ionization; and concentration gradient.

Question 2

The most common method of drug absorption is ______.

Answer 2

lipid diffusion through the membrane

Question 3

Bioavailability is also called _______.

Answer 3

extent of absorption

Question 4

F (fraction bioavailable) = _____.

Answer 4

(AUC route) / (AUC iv)

Question 5

First pass effect is best described as ______.

Answer 5

the hepatic or gastric metabolism of a drug prior to entry in to the systemic circulation

Question 6

Rate of drug absorption can be decreased by ________.

Answer 6

coating pills in enteric products

Question 7

A generic product is bioequivalent to a brand product if _____ are within set limits.

Answer 7

the rate (estimated by Cp and Tmax) and extent (bioavailable portion)

Question 8

Drugs that are _______ have high bioavailability.

Answer 8

hydrophobic but stable in aqueous solutions

Question 9

The most bioavailable and fast route is ___.

Answer 9

IV

Question 10

Does transdermal or dermal absorb systemically?

Answer 10

Transdermal