Exam 2 Miscellaneous

Question 1

Coagulative necroses are seen in ______.

Answer 1

heart myocytes

Question 2

Liquefactive necroses are seen in ______.

Answer 2

brain and spleen

Question 3

______ does not protect against reactive oxygen species, but glutathione peroxidase, catalase, and superoxide dismutase do.

Answer 3

Xanthine peroxidase

Question 4

Does platelet activating factor have systemic effects?

Answer 4

No

Question 5

Factor XII manifests with pain because ________.

Answer 5

it activates kallikrein which in turn converts kinin to bradykinin

Question 6

Factor XII activates _____.

Answer 6

C5

Question 7

What does granulation tissue do?

Answer 7

It lays down the framework on which new epithelium can be laid, but it does not re-epithelialize.

Question 8

I-CAM helps ________.

Answer 8

leukocytes migrate into tissues

Question 9

Selectins help ______, while integrins help ______.

Answer 9

in rolling; in adhesion

Question 10

Fibroblast proliferation, macrophages, and neo-vascularization would be seen in ______.

Answer 10

granulation tissue

Question 11

What makes D-dimer levels increase?

Answer 11

Breakdown of fibrin in clotting

Question 12

Red infarctions typically affect ________.

Answer 12

loose tissues (like the lungs or testis), tissues with multiple blood supplies, and tissues with obstructed venous outflow

Question 13

Snail, twist, and Zeb 1/2 are ______.

Answer 13

transcriptional repressors of E-cadherin

Question 14

Anti-topoisomerase agents work by ______.

Answer 14

DNA double stranded breaks

Question 15

Prostate cancer usually occurs in the _____.

Answer 15

periphery of the prostate

Question 16

The type of lung cancer that is least associated with smoking is _____.

Answer 16

bronchioalveolar carcinoma

Question 17

Cytotoxic agents can ________.

Answer 17

target a specific enzyme, but targeted agents hit specific enzymes that are faulty in cancer cells only

Question 18

A cancer that has invaded regional lymph nodes but not metastasized is _____.

Answer 18

stage III

Question 19

Tumors in the ascending colon typically _____.

Answer 19

protrude into the lumen

Question 20

List the causes of cancer death from most to least frequent.

Answer 20

Infection, organ failure, thromboembolism, hemorrhage, emaciation

Question 21

Aspiring overdoses involve ______.

Answer 21

rashes, hepatomegaly, and somnolence

Question 22

What adhesion molecule normally expressed on T lymphocytes is co-opted by tumor cells?

Answer 22

CD44

Question 23

Polyaromatic hydrocarbons metabolize to ______.

Answer 23

epoxides

Question 24

_______ is a definitive pathologic sign of alcoholic hepatitis.

Answer 24

Alcoholic hyaline

Question 25

Cortisol is ____ acting.

Answer 25

short

Question 26

Amoeboid movement occurs _________.

Answer 26

quickly via collagen fibers