Pharmacokinetics - Drug Distribution Flashcards
1
Q
What are the three sites in which epithelial cells are tightly linked together–through which drugs cannot pass through fenestrations?
A
The GI tract, the CNS, and renal tubules
2
Q
Strong acids have _____ pKas.
A
low (HI has a pKa of -10)
3
Q
Strong bases have _____ pKas.
A
high (OH- has a pKa of 15.7)
4
Q
When pH>pKa, the _______ form dominates.
A
deprotonated
5
Q
When pH
A
protonated
6
Q
Protein binding ____ the free concentration and _____ the degradation.
A
reduces; slows
7
Q
Vd (volume of distribution) is equal to ______.
A
(amount of drug in patient) / (extrapolated concentration at time zero)
