Pharma: Exceptional drugs

Question 1

Beta blockers without local anesthetic activity

Answer 1

Timolol and betaxolol

Question 2

Glaucoma
Drug class that opens the trabecular meshwork by ciliary muscle contraction

Answer 2

Cholinomimetics

Pilocarpine

Question 3

Glaucoma

Increases outflow via canal of Schlemm

Answer 3

Prostaglandins

Question 4

Glaucoma

Increases outflow via uveoscleral/episcleral veins

Answer 4

Non selective a-agonists

Question 5

Non-sulfa loop diuretic

Answer 5

Ethacrynic acid

Question 6

Better prostatic smooth muscle activity

Answer 6

Tamsulosin

Question 7

B blocker with direct vasodilating properties

Answer 7

Nebivolol

Question 8

Vasodilator that decreases insulin release

Answer 8

Diazoxide

Question 9

Which?
Dihydropyridine or non-dihydropyridine
Vascular > cardiac activity

Answer 9

Dihydropyridine

Nifedipine

Question 10

Class 1B antiarrhythmic that causes agranulocytosis

Answer 10

Tocainide

Question 11

Class 1A antiarrhythmic that causes ITP

Answer 11

Quinidine

Question 12

Beta blockers with intrinsic sympathomimetic activity

Answer 12

Pindolol, acebutolol

Question 13

Least cardiotoxic conventional antiarrhythmic

Answer 13

Lidocaine

Question 14

Beta blocker with class 3 properties

Answer 14

Sotalol

Question 15

Hallmark of Class 3 antiarrhythmics

Answer 15

prolonged AP secondary to blockade of Ik potassium channels that repolarize the membrane.

Increases the Effective refractory period

Question 16

Unique side effect of amiodarone

Answer 16

Microcrystalline deposits in the cornea and skin

Others: pulmonary fibrosis

Question 17

Drug of choice for paroxysmal SVT

Answer 17

Adenosine

also, effects of this drug last only 15 seconds.

Question 18

Diuretic that acts on the basal side of the renal cells

Answer 18

Aldosterone receptor antagonists

Question 19

Loop diuretic that is also a uricosuric diuretic

Answer 19

Ethacrynic acid

Question 20

What drug has anti-ADH properties but is never used for that purpose

Answer 20

Lithium

Question 21

Drug most effective in raising HDL

Answer 21

Niacin

Question 22

Drugs used for phytosterolemia

Answer 22

Ezetimibe - inhibitor of NPC1L1

Sitosterol - cholesterol analog (absorbed in the place of secreted bile and phytosterols)

Question 23

Anti-hyperlipidemic disadvantageous combinations:
Fibrate + Resin
Statin + Resin
Statin + Fibrate

Answer 23

Fibrate + Resin: increased risk of cholelithiasis
Statin + Resin: impaired statin absorption
Statin + Fibrate: increased risk of myopathy and rhabdomyolysis

Question 24

Prototype antagonist versus the serotonergic effects of carcinoid syndrome

Answer 24

Carcinoid syndrome: 5-HT2 effects
Antagonist: Ketanserin

DOC is still Cyproheptadine

Question 25

Notable side effect of methysergide

Answer 25

Retroperitoneal fibrosis

Question 26

Teratogenic effect of misoprostol

Answer 26

Mobious sequence

Question 27

2 2nd gen H1-receptor antagonists that cause fatal arrhythmias when given with azoles or erythromycin

Answer 27

Terfenadine

Astemizole

Question 28

Prostaglandins Mnemonic Card

Answer 28

PGE1: Prostol
PGE2: Prostone
PGI2: Prostenol
PGF2: Prost

Question 29

Prostaglandin used for cervical ripening

Answer 29

Dinoprostone

Question 30

Antidote for theophylline overdosage

Answer 30

B-blockers

Question 31

Methylxanthine that decreases blood viscosity

Answer 31

Pentoxifylline

Question 32

Used for aspirin induced bronchospasm

Answer 32

Zileuton (5-lipooxygenase inhibitor)

Question 33

Anti-IgE antibody for severe, refractory asthma

Answer 33

Omalizumab