Biochem: Misc Flashcards
What is the most common genetic error of amino acid transport?
Cystinuria
Proteins rich in which sequences are rapidly degrades?
PEST sequence. Proline glutamate Serine and threonine
2 amino acids the do NOT undergo transamination
Lysine and threonine lose amino groups by deamination
Which has better Sn/ Sp for liver dz?
AST
ALT?
Sp ALT (L for liver) Sn AST
3 etiologies for extensive rise in AST ALT?
Ischemia
Toxins
Severe hepatitis
Name all ketogenic AA.
Which are BOTH glucogenic and ketogenic?
Both phe, tyr, isoleucine, trp (PeTITe)
Ketogenic Leucine and lysine (ketong leprosy)
2 sites for heme synthesis
Bone marrow ERYTHROID CELLS and liver
Immediate precursor of BOTH stercobilin and urobilin
Urobilinogen
Identify if conjugated or unconjugated hyperbilirubinemia Dublin Johnson Rotor Crigler Najjar Gilbert Gilbert
DR CONJUGATED
GC UNCOJUGATED
Is the reaction spontaneous?
- Negative enthalpy negative entropy?
- Positive both
1 only at low temp
2 only at high temp
Which GLUT? Brain RBC Liver Pancreas Heart fat and skeletal muscle
Brain 1 and 3
RBC 1
Liver Pancreas 2
Heart fat and skeletal muscle 4
What are the strictly glycolytic organs of the body?
RBC WBC
lens cornea
kidneys
testes
Pyruvate turns into? Lactate dehydrogenase Pyruvate dehydrogenase Pyruvate decarboxylase Pyruvate carboxylase
Lactate dehydrogenase lactate
Pyruvate dehydrogenase acetyl coa
Pyruvate decarboxylase ethanol
Pyruvate carboxylase oxaloacetate
What lipoprotein has MOST 1 TG 2 cholesterol 3 protein 4 cholesterol ester
1 TG chylomicrons
2 cholesterol LDL
3 protein HDL
4 cholesterol ester LDL
Arsenic poisoning will manifest as rice water stools, garlic breath and vomiting. Which enzymes were affected?
Pyruvate and alpha ketoglutarate dehydrogenase are both affected as arsenic INHIBITS LIPOIC ACID
