Pathology: Misc

Question 1

Give examples of cancers that are locally invasive but do NOT send mets.

Answer 1

Basal cell CA and CNS primaries.

Question 2

Name preferential mets:
Prostate
Bronchogenic CA
Neuroblastoma

Answer 2

Prostate bone
Bronchogenic CA adrenals and brain
Neuroblastoma liver and bones

Question 3

Occupational CA
Benzene
Beryllium
Cadmium
NIckel
Chromium
VInyl chloride

Answer 3

Benzene Leukemia
Beryllium Lung
Cadmium Prostate
NIckel Nose and lung
Chromium Lung
VInyl chloride Angiosarcoma of the liver

Question 4

What is the only gene mutation that results in a GENERALIZED PREDILECTION FOR CANCERS?

Answer 4

p53 in Li Fraumeni

Question 5

Mutation of what gene can lead to cellular (malignant) transformation even if only a SINGLE ALLELE?

Oncogene
Tumor supressor

Answer 5

Oncogene

Question 6

Which is the governor and which is the guardian?
p53
RB

Answer 6

RB governor more R’s in governor

p53 guardian

Question 7

Determine what results in these translocations of chromosomes
22 and 9
8 and 14

Answer 7

22 and 9: CML

8 and 14: Burkitt’s lymphoma MYC overexpression

Question 8

Determine what gene is affected with the ff deletions:
13q4
17p

Answer 8

13q4 RB gene

17p p53

Question 9

Amplification of the following genes results in?
NMYC
ERBB2 aka HER2/NEU

Answer 9

NMYC Neuroblastoma

ERBB2 aka HER2/NEU Breast cancer

Question 10

What is the most prevalent chronic occupational disease in the world?

Answer 10

Silicosis

Quartz crysalline silicosis is the most toxic and fibrinogenic