Pharm: Smooth Muscle Flashcards

1
Q

MOA, indication/s, toxicities:

SUMATRIPTAN

A

5HT1D agonist.
Migraine and cluster headache.
Paresthesia, dizziness, chest pain.

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2
Q

MOA, indication/s, toxicities

DIPHENHYDRAMINE

A

H1 blocker.
Hay fever, angioedema, motion sickness.
Sedation, autonomic block.

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3
Q

Therapy for neuroleptic malignant syndrome

A

Diphenhydramine

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4
Q

MOA, indication/s, toxicities:

CIMETIDINE

A
H2 blocker.
Acid peptic disease.
Inhibitor of CYP450 enzymes;
anti androgen effect
(man boobies!!!)
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5
Q

MOA, indication/s:

BROMOCRIPTINE

A

D2 receptor agonist

Hyperprolactinemia, Parkinsonism.

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6
Q

This parenteral kallikrein inhibitor is approved for use in angioedema

A

Ecallantide

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7
Q

Capsaicin is used in arthritic joints and post-herpetic neuralgia. What is its MOA?

A

Release substance P in nerve endings

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8
Q

Most potent hypotensive agent

A

CGRP

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9
Q

MOA, indication/s, toxicities

BOSENTAN

A

Endothelin A and endothelin B receptor ANTAgonist.
Pulmonary HTN.
Hepatic impairment, possible teratogen

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10
Q

MOA, indication/s, toxicities

APREPITANT

A

Tachykinin NK1 receptor blocker.
Antiemetic for chemotherapy-induced vomiting.
Asthenia, hiccups.

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11
Q

Name that eicosanoid:

  1. Protective effect on gastric mucosa
  2. Slow reacting substance of anaphylaxis
  3. Natural vasodilator that maintains patency of the ductus arteriosus
  4. Causes dysmenorrhea and may play a time in labor
A
  1. PGE1
  2. LTC4 and LTD4 (LTB4)
  3. PGE2
  4. PGE2 and PGF2alpha
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12
Q

MOA, indication/s, toxicities

DINOPROSTONE

A

PGE2
Abortifacient; cervical ripening.
Cramping, fetal trauma

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13
Q

MOA, indication/s, toxicities:

LATANOPROST

A

PGF2a derivative
Glaucoma
Color change in iris

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14
Q

MOA, indication/s, toxicities:

MISOPROSTOL

A

PGE1 derivative
Protective agent in PUD, abortifacient.
Diarrhea, uterine cramping.

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15
Q

This PGE1 analog is injected in the corpora as treatment for erectile dysfunction

A

Alprostadil

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16
Q

MOA, indication/s, toxicities:

EPOPROSTENOL

A

PGI2
Vasodilator in pulmonary HPN;
Antiplatelet in extra corporeal dialysis.
Hypotension, flushing.

17
Q

MOA, indication/s, toxicities:

MONTELUKAST

A

Block CysLT1 receptor.
Asthma prophylaxis.
Liver enzyme elevation

18
Q

Albuterol is a short acting beta agonist. What is its duration of action? Salmeterol?

A

SABA: 4h or less
LABA: 12h

19
Q

Which drugs cause endogenous NO release by stimulating its synthesis by NOS?

A

Muscarinic agonist
Histamine
Bradykinin
Hydralazine

20
Q

MOA, indication/s, toxicities

ZILEUTON

A

Lipooxygenase inhibitor
Asthma prophylaxis
Elevation of liver enzymes

21
Q

MOA, indication/s, toxicities

CROMOLYN

A

Mast cell stabilizer
Asthma prophylaxis
Cough

22
Q

MOA, indication/s, toxicities:

ONDANSETRON

A

5HT3 blocker
Chemotherapy and postoperative vomiting
QT prolongation, possible arrhythmia