Pharm: Smooth Muscle

Question 1

MOA, indication/s, toxicities:

SUMATRIPTAN

Answer 1

5HT1D agonist.
Migraine and cluster headache.
Paresthesia, dizziness, chest pain.

Question 2

MOA, indication/s, toxicities

DIPHENHYDRAMINE

Answer 2

H1 blocker.
Hay fever, angioedema, motion sickness.
Sedation, autonomic block.

Question 3

Therapy for neuroleptic malignant syndrome

Answer 3

Diphenhydramine

Question 4

MOA, indication/s, toxicities:

CIMETIDINE

Answer 4

H2 blocker.
Acid peptic disease.
Inhibitor of CYP450 enzymes;
anti androgen effect
(man boobies!!!)

Question 5

MOA, indication/s:

BROMOCRIPTINE

Answer 5

D2 receptor agonist

Hyperprolactinemia, Parkinsonism.

Question 6

This parenteral kallikrein inhibitor is approved for use in angioedema

Answer 6

Ecallantide

Question 7

Capsaicin is used in arthritic joints and post-herpetic neuralgia. What is its MOA?

Answer 7

Release substance P in nerve endings

Question 8

Most potent hypotensive agent

Answer 8

CGRP

Question 9

MOA, indication/s, toxicities

BOSENTAN

Answer 9

Endothelin A and endothelin B receptor ANTAgonist.
Pulmonary HTN.
Hepatic impairment, possible teratogen

Question 10

MOA, indication/s, toxicities

APREPITANT

Answer 10

Tachykinin NK1 receptor blocker.
Antiemetic for chemotherapy-induced vomiting.
Asthenia, hiccups.

Question 11

Name that eicosanoid:

1. Protective effect on gastric mucosa
2. Slow reacting substance of anaphylaxis
3. Natural vasodilator that maintains patency of the ductus arteriosus
4. Causes dysmenorrhea and may play a time in labor

Answer 11

1. PGE1
2. LTC4 and LTD4 (LTB4)
3. PGE2
4. PGE2 and PGF2alpha

Question 12

MOA, indication/s, toxicities

DINOPROSTONE

Answer 12

PGE2
Abortifacient; cervical ripening.
Cramping, fetal trauma

Question 13

MOA, indication/s, toxicities:

LATANOPROST

Answer 13

PGF2a derivative
Glaucoma
Color change in iris

Question 14

MOA, indication/s, toxicities:

MISOPROSTOL

Answer 14

PGE1 derivative
Protective agent in PUD, abortifacient.
Diarrhea, uterine cramping.

Question 15

This PGE1 analog is injected in the corpora as treatment for erectile dysfunction

Answer 15

Alprostadil

Question 16

MOA, indication/s, toxicities:

EPOPROSTENOL

Answer 16

PGI2
Vasodilator in pulmonary HPN;
Antiplatelet in extra corporeal dialysis.
Hypotension, flushing.

Question 17

MOA, indication/s, toxicities:

MONTELUKAST

Answer 17

Block CysLT1 receptor.
Asthma prophylaxis.
Liver enzyme elevation

Question 18

Albuterol is a short acting beta agonist. What is its duration of action? Salmeterol?

Answer 18

SABA: 4h or less
LABA: 12h

Question 19

Which drugs cause endogenous NO release by stimulating its synthesis by NOS?

Answer 19

Muscarinic agonist
Histamine
Bradykinin
Hydralazine

Question 20

MOA, indication/s, toxicities

ZILEUTON

Answer 20

Lipooxygenase inhibitor
Asthma prophylaxis
Elevation of liver enzymes

Question 21

MOA, indication/s, toxicities

CROMOLYN

Answer 21

Mast cell stabilizer
Asthma prophylaxis
Cough

Question 22

MOA, indication/s, toxicities:

ONDANSETRON

Answer 22

5HT3 blocker
Chemotherapy and postoperative vomiting
QT prolongation, possible arrhythmia