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Y1S2 > PHARM Lipid-Lowering Drugs > Flashcards

PHARM Lipid-Lowering Drugs Flashcards

1
Q

Familial hypercholesterolaemia pathology

A

Pts lack LDL receptors. Cannot regulate LDL entry into cell.

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2
Q

Exogenous vs endogenous pathway

A

Exo: Derived from GIT… Cholesterol -> intestinal lymph (transported as chylomicrons) -> plasma (hydrolysed) -> muscle/adipose tissue
Endo: Synthesised in liver… Cholesterol (VLDL) -> muscle/adipose tissue -> lipoprotein particles become LDL

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