PHARM DMARDs

Question 1

Purulent Inflammation

Answer 1

Purulent inflammation – inflammation resulting in large amounts of pus, which consists of neutrophils, dead cells & fluid.

Question 2

Abscess

Answer 2

Abscess – confined pocket of pus that collects in tissues, organs or spaces inside the body.

Question 3

Arthritis vs althralgia

Answer 3

Arthritis vs arthralgia - arthritis is an umbrella term for several inflammatory joint conditions, while arthralgia is a medical term for joint pain without inflammation.

Question 4

DMARD expand.

Answer 4

Disease Modifying Anti-Rheumatic Drugs.

Question 5

How are WBCs affected by DMARDs?

Answer 5

Decreased production, proliferation, function, activation/communication.

Question 6

MOA allopurinol

Answer 6

Inhibits xanthine oxidase which synthesises uric acid.

Question 7

MOA probenecid.

Answer 7

Increase uric acid conc./excretion in urine by blocking reabsorption of uric acid via kidneys.

Question 8

MOA Colchicine

Answer 8

Binds to microtubules of neutrophils and inhibits chemotaxis.

Question 9

Gout

Answer 9

Too many WBCs -> uric acid deposits -> synovitis

Question 10

NSAIDs vs DMARDs for RA treatment.

Answer 10

DMARDs - arrest disease progression, slow, used in chronic cases, prevent formation of new deformities
NSAIDs - used in acute cases, rapid, cannot stop deformities, do not slow progression of disease.

Question 11

Examples of DMARDs which affects WBC production/replication.

Answer 11

Methotrexate - via interfering with dihydrofolate reductase (DFHR) enzyme.
Leflunomide.

Question 12

MOA Prednisolone

Answer 12

Binds to glucocorticoid receptors to inhibit pro-inflammatory signals and reduce inflammation.

Question 13

Site of RA inflammation.

Answer 13

Synovial membrane.