MICRO Viral Pathogenesis

Question 1

Cytopathology

Answer 1

Direct damage to tissues caused by cell lysis due to viral replication.

Question 2

Oncogenesis

Answer 2

Viral infection either activates oncogenes/inactivates tumour suppressors.

Question 3

Immunopathology

Answer 3

Damage to tissues/organs caused by the host response leads to inflammation, auto-immunity, cytokine/lymphocyte deregulation.

Question 4

What must be done to enable translation of -ve sense RNA?

Answer 4

Transcribed first into its complement.

Question 5

Describe immunopathology associated with re-infection w dengue.

Answer 5

Monocytes are not susceptible to dengue upon initial exposure…If pre-existing antibodies are present from a previous infection, a second exposure to dengue allows antibody-virus conjugates to bind Fc receptors -> facilitating virus uptake into these cells (which are normally non-susceptible).