Penicillinase resistance penicillins

Question 1

What is an example of penicillinase resistance penicillin?

Answer 1

Flucloxicillin

Question 2

What is the method of action of penicillinase resistance penicillin?

Answer 2

• B lactam rings inhibits the enzymes responsible for cross linking peptidoglycan in the bacteria cell walls
• = Weakened cell walls so cannot maintain an osmotic gradient

Question 3

What are the indications for penicillinase resistance penicillin?

Answer 3

• Skin and soft tissue infections e.g. cellulitis
• Osteomyelitis
• Septic arthritis
• Other infections inc. endocarditis

Question 4

What are the contraindications for penicillinase resistance penicillin?

Answer 4

• Renal failure – dose ↓ required
• History of penicillin allergy
• Prior flucloxacillin related hepatotoxicity

Question 5

What are the side effects of penicillinase resistance penicillin?

Answer 5

• GI upset
• Penicillin allergy – skin rash → anaphylactic reaction
• Liver toxicity inc. cholestasis and hepatitis
• Central nervous system toxicity – in high doses/severe renal impairment

Question 6

What are the drug interactions with penicillinase resistance penicillin?

Answer 6

• Methotrexate – penicillin ↓ renal excretion = toxicity

Question 7

What organ eliminates penicillinase resistance penicillin?

Answer 7

• Kidney