Aminosalicylates

Question 1

What are the generic and brand names for aminosalicylates?

Answer 1

• Mesalazine (Pentasa, Asacol)

* Sulfasalazine

Question 2

What are the methods of action of aminoxalicylates?

Answer 2

• Releases 5-aminosalicylic acid
• Acts on the gut only
• Provides an ant-inflammatory and immunosuppressant effect – not really understood how

Question 3

What are the indications for aminosalicylates?

Answer 3

• Ulcerative colitis

* Rheumatoid arthritis (Sulfasalazine only)

Question 4

What are the contraindications for aminosalicylates?

Answer 4

• Salicylate/aspirin sensitivity

* Children under the age of 2

Question 5

What are the side effects of aminosalicylates?

Answer 5

• GI upset
• Headache
• Cell abnormalities (leucopenia, thrombocytopenia, oliospermia)
• Renal impairment

Question 6

What are the interactions with aminosalicylates?

Answer 6

• Drugs that alter the pH of the gut – PPI, lactulose

Question 7

What is the route of elimination of aminosalicylates?

Answer 7

Kidney

Question 8

What patient information should be given for aminosalicylates?

Answer 8

• Ask patient to explain any unexplained bleeding/bruising – sign of blood count abnormality