Antiemetics – serotonin 5-HT3 receptor antagonists Flashcards
1
Q
What are the generic and brand names for serotonin 5-HT3 receptor antagonists?
A
• Ondansetron
2
Q
What is the method of action of serotonin 5-HT3 receptor antagonists?
A
- Blocks high numbers of 5-HT3 receptors in the chemoreceptor trigger zone in the brain that senses substances that makes the body sick
- Blocks serotonin which is a neurotransmitter in the gut that stimulates the vagus nerve and activates the vomiting centre
3
Q
What are the indications for serotonin 5-HT3 receptor antagonists?
A
- Prophylaxis of nausea and vomiting
- Treatment of nausea and vomiting
- Mainly used in GA and chemotherapy
4
Q
What are the contraindications for serotonin 5-HT3 receptor antagonists?
A
• Prolonged QT interval
5
Q
What are the side effects of serotonin 5-HT3 receptor antagonists?
A
- Constipation
- Diarrhoea
- Headaches
- Prolonging QT interval
6
Q
What are the interactions of serotonin 5-HT3 receptor antagonists?
A
• Drugs the prolong QT interval – antipsychotics, quinine, SSRIs
