Angiotensin II receptor blockers Flashcards
1
Q
What are the generic and brand names of Angiotensin II receptor blockers?
A
- Losartan (Cozaar)
- Irbesartan (Aprivel)
- Candesartan (Amias)
2
Q
What is the method of action of Angiotensin II receptor blockers?
A
- Angiotensin II is a potent vasoconstrictor and causes the release of angiotensin
- Stops the binding of angiotensin II on the AT1 receptor
- Lowers blood pressure and reduces action of peripheral vascular resistance
- Dilation of efferent glomerular arteriole = lower pressure and progression of CKD
3
Q
What are the indications of Angiotensin II receptor blockers?
A
- Hypertension – 1st/2nd line
- Chronic heart failure
- Ischemic heart disease
- Diabetic nephropathy and CKD
4
Q
What are the contraindications of Angiotensin II receptor blockers?
A
- Renal artery stenosis
- AKI
- Pregnant/breastfeeding
- CKD
5
Q
What are the side effects of Angiotensin II receptor blockers?
A
- Dizziness
- Hyperkalaemia
- Renal failure
6
Q
What are the interactions with Angiotensin II receptor blockers?
A
- Potassium elevating drugs e.g. potassium supplements, potassium sparing diuretics
- NSAID
7
Q
Which organ eliminates Angiotensin II receptor blockers?
A
Kidney
8
Q
What patient information should be given to a patient taking Angiotensin II receptor blockers?
A
- Best taken before bed
- Avoid NSAID
- Blood test monitoring will be required
