Pathogenesis of Dementia

Question 1

Neuro degen diseases associated with?

Answer 1

abnormal protein conformations

Question 2

Alzheimer’s genetic risk found on which chromosome?

Answer 2

chromosome 21 (APP mutations)

Question 3

Alzheimer’s risk ____ with each decade after 50?

Answer 3

doubles

Question 4

4 types of Alzheimer’s disease?

Answer 4

1. amnestic (temporal)
2. visuospatial (R>L)
3. aphasic (L>R)
4. frontal

Question 5

what happens to aberrant Abeta monomers?

Answer 5

aggregate to become Amyloid Plaques + inflammation = neuron death

Question 6

Where do the Abeta monomers/oligomers aggregate?

Answer 6

extra/intra synaptic sites and surfaces of neurons

Question 7

what is the metal-protein attenuating compound targeting in Alzheimer’s?

Answer 7

Abeta oligomers

Question 8

how to scan for Abeta plaques?

Answer 8

inject carbon 11-PIB to stick to amyloids and PET scan

Question 9

Alzheimer’s on average takes how long to cause death?

Answer 9

30 years

Question 10

spongiform encephalopathy causes death in how long?

Answer 10

6 months!

Question 11

CJD odds?

Answer 11

1:1000 000

Question 12

CJD is an infectious?

Answer 12

protein

Question 13

CJD causes what in the brain?

Answer 13

fluid filled holes in the brain

Question 14

what is PrPc and PrPres?

Answer 14

PrPres is resistant to degradation and insoluble

Question 15

polymorphism where will determine susceptibility to PrPres?

Answer 15

M129 aka Methionine 129

Question 16

vCJD into lymph nodes, implications?

Answer 16

circulating in blood stream, risk of blood transmission

Question 17

incubation period for vCJD in blood?

Answer 17

6-15 years

Question 18

Parkinson’s protein misfold?

Answer 18

a-synuclein

Question 19

Parkinson’s a-synuclein leads to formation of what?

Answer 19

Lewy Bodies