Behavioural Illness

Question 1

Catatonia is?

Answer 1

motor immobility

extreme negativism/mutism

Question 2

Islands of Reil AKA?

Answer 2

Insular cortex

Question 3

Mental developmental disorders tend to start when?

Answer 3

puberty

Question 4

what two types of glial cells are involved in behavioural illness?

Answer 4

microglia

astrocytes

Question 5

how much metabolic rate is for brain?

Answer 5

25%

Question 6

suggested that schizophrenia, problem with what in the synapses?

Answer 6

pruning

formulation

Question 7

when does synaptic pruning happen in sensory cortex vs. frontal?

Answer 7

sensory: early
frontal: late

Question 8

dendritic spine density in children is?

Answer 8

2-3x greater than adults

Question 9

what’s the most replicable finding of anatomical basis for mental illness?

Answer 9

connectivity

Question 10

what regulates cell skeleton?

Answer 10

Wnt
GSK3b
synapsinI
MAP2

Question 11

Schizophrenia have higher levels of what in microglia?

Answer 11

calprotectin

Question 12

Mouse OCD with Hoxb8 can be rescued how?

Answer 12

bone marrow transplant

Question 13

autism and microglia, which region and what happens?

Answer 13

dorsolateral prefrontal cortex (both white and bray matter)

overgrowth

Question 14

increased what staining in autism?

Answer 14

HLA-DR

Question 15

does increased density in DLPFC in autism is NOT related to? 2 things

Answer 15

seizures

inflammation

Question 16

SNPs are?

Answer 16

single nucleotide polymorphism

Question 17

Genetic classification of autism spectrum is 1st time we have what?

Answer 17

diagnostic test

Question 18

where to parents of autistic children lie on the graph/spectrum?

Answer 18

between the control and autism subject scores

Question 19

getting autism seems to be a balance between what genetically?

Answer 19

risk SNPs

resilience SNPs

Question 20

do both monozygotic twins have to have autism if one has one?

Answer 20

Nope. One twin can have more protective SNPs