Aging & Frailty Flashcards
Robert Butler coined term:
Ageism
Rectangularisation of survival curves means?
compressing mortality
Cellular senescence is?
cells lose ability to divide
what causes cellular senescence?
DNA damage, Telomeres, apotosis
older people have decreased what to respond to challenges?
reserve
How is homeostasis in elderly person?
harder to maintain
what is successful ageing?
changes due only to the aging process and not disease or other factors
what is usual ageing?
combined effects of aging and disease and environment/lifestyle
Frailty is diminished ability to do what?
carry out ADLs
Frailty and stress?
harder to respond, reduced capacity, easier to unbalance
Frailty as a clinical syndrome?
low-grade inflammatory response
What biomarkers is frailty associated with?
IL-6 and TNFa, C-reactive protein
IL-6 is predictive of?
functional decline/muscle mass
what is sarcopenia?
decreased muscle mass due to altered CNS/PNS, hormones, cytokines, disuse
when does skeletal muscle mass start to decline?
3rd decade
what muscle type loses faster?
Type 2 > Type 1
What is Fried’s Frailty Criteria? 5
- unintentional weight loss
- weakness
- exhaustion
- slow walking speed
- low physical activity
Co-morbidity def’n?
> 2 chronic diseases
Disability is defined as?
physical or mental impairment that limits >1 major ADL
Frailty definition?
high vulnerability to adverse health outcomes
Co-morbidity health care implications?
harder to coordinate, polypharmacy, fragmentaion
medical syndrome is?
grouping of multiple symptoms to have single dx or disease
geriatric syndrome is?
accumulated effect of impairments in multiple domains = adverse outcome
multiple morbid processes
5 Giants of Geriatric MEdicine?
Incontinence Immobility Impaired balance Impaired cognition (delirium/dementia) iatrogenic
