Aging & Frailty

Question 0

Robert Butler coined term:

Answer 0

Ageism

Question 1

Rectangularisation of survival curves means?

Answer 1

compressing mortality

Question 2

Cellular senescence is?

Answer 2

cells lose ability to divide

Question 3

what causes cellular senescence?

Answer 3

DNA damage, Telomeres, apotosis

Question 4

older people have decreased what to respond to challenges?

Answer 4

reserve

Question 5

How is homeostasis in elderly person?

Answer 5

harder to maintain

Question 6

what is successful ageing?

Answer 6

changes due only to the aging process and not disease or other factors

Question 7

what is usual ageing?

Answer 7

combined effects of aging and disease and environment/lifestyle

Question 8

Frailty is diminished ability to do what?

Answer 8

carry out ADLs

Question 9

Frailty and stress?

Answer 9

harder to respond, reduced capacity, easier to unbalance

Question 10

Frailty as a clinical syndrome?

Answer 10

low-grade inflammatory response

Question 11

What biomarkers is frailty associated with?

Answer 11

IL-6 and TNFa, C-reactive protein

Question 12

IL-6 is predictive of?

Answer 12

functional decline/muscle mass

Question 13

what is sarcopenia?

Answer 13

decreased muscle mass due to altered CNS/PNS, hormones, cytokines, disuse

Question 14

when does skeletal muscle mass start to decline?

Answer 14

3rd decade

Question 15

what muscle type loses faster?

Answer 15

Type 2 > Type 1

Question 16

What is Fried’s Frailty Criteria? 5

Answer 16

1. unintentional weight loss
2. weakness
3. exhaustion
4. slow walking speed
5. low physical activity

Question 17

Co-morbidity def’n?

Answer 17

> 2 chronic diseases

Question 18

Disability is defined as?

Answer 18

physical or mental impairment that limits >1 major ADL

Question 19

Frailty definition?

Answer 19

high vulnerability to adverse health outcomes

Question 20

Co-morbidity health care implications?

Answer 20

harder to coordinate, polypharmacy, fragmentaion

Question 21

medical syndrome is?

Answer 21

grouping of multiple symptoms to have single dx or disease

Question 22

geriatric syndrome is?

Answer 22

accumulated effect of impairments in multiple domains = adverse outcome
multiple morbid processes

Question 23

5 Giants of Geriatric MEdicine?

Answer 23

Incontinence
Immobility
Impaired balance
Impaired cognition (delirium/dementia)
iatrogenic