Drug Dependence/Antidepressants

Question 1

what is drug dependence

Answer 1

compulsive taking of drug

Question 2

what is drug abuse?

Answer 2

illicit substance use
illicit use of legal substances
recurrent use/adverse consequences

Question 3

what is habituation/adaptation in drug abuse?

Answer 3

rely on drug to avoid negative symptoms of withdrawal

Question 4

reward pathways involve what NT system? where?

Answer 4

dopimanergic in nucleus accumbens

Question 5

Amphetamines displace NA from vesicles and also 2 other NTs? which is it better at releasing?

Answer 5

5-HT
DA
better at releasing these two than NA

Question 6

MDMA releases what? what does it do?

Answer 6

1. Dopamine/serotonin

2. stimulant/hallucinogenic

Question 7

MDMA is tweaked version of what drug?

Answer 7

amphetamines

Question 8

what happens the next time you take LSD?

Answer 8

need higher dose

cross-tolerance with other psychotomimetics

Question 9

LSD activates what on 5-HT neurons?

Answer 9

autoreceptors in Raphe

Question 10

Caffeine drug class?

Answer 10

Mathylxanthine

Question 11

Caffeine blocks what?

Answer 11

adenosine antagonist

phosphdiesterase inhibitor

Question 12

Alcohol can cause what at higher doses? does what to CNS?

Answer 12

causes Aggression

is a depressant

Question 13

Alcohol inhibits what receptors? enhances what?

Answer 13

inhibits glutamate: NMDA

enhances GABA-A

Question 14

what is abstinence syndrome?

Answer 14

eg. ethanol, feel so bad coming off, you just stay on

Question 15

D9-THC is what? causes?

Answer 15

relaxation: no aggression

sharpened sensory awareness

Question 16

D9-THC attaches to what receptors?

Answer 16

Cannabinoid receptors

Question 17

2 kinds of cannabinoid receptors:

Answer 17

CB1: central
CB2: peripheral

Question 18

antidepressants:1st, 2nd, 3rd generation?

Answer 18

1st: tricyclic/MAO inhibitors
2nd: SSRIs
3rd: novel MAO

Question 19

Tricyclics did what? what was bad?

Answer 19

inhibit reuptake of NA and serotonin

poor selectivity

Question 20

disadvantage of tricyclics

Answer 20

1. week to develop
2. narrow therapeutic window
3. gradual accumulation of side effects

Question 21

MAO inhibitors did what?

Answer 21

increase 5-HT, NA, DA

Question 22

What is the cheese reaction for MAO inhibitors?

Answer 22

in irreverisble MAOs: tyramine = hypertensive crisis

Question 23

Reversible MAO inhibitors were better why?

Answer 23

less cheese reaction

MAOa selective

Question 24

SSRIs did what? why was is good?

Answer 24

inhibit only serotonin reuptake

large therapeutic window

Question 25

SSRI caution use in what population?

Answer 25

adolescents due to suicide