Pain & Somatosensory Disorders Flashcards

1
Q

Overview of somatosensory system

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Sensory receptors are classified into five categories. What are these?

A
  1. Chemoreceptors; chemicals
  2. Thermoreceptors; temperature
  3. Mechanoreceptors; pressure
  4. Proprioceptors
  5. Nociceptor; pain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

A number of receptors are distributed throughout the skin to respond to various touch-related stimuli. Name these 4 receptors?

N.B. these are all mechanoreceptors

A
  1. Pacinian corpuscle
  2. Ruffini’s corpuscles
  3. Merkel’s disks
  4. Free nerve endings
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the four major types of tactile mechanoreceptors?

A

Merkel’s disks, Meissner’s corpuscles, Ruffini endings, and Pacinian corpuscles.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How do mechanoreceptors sense stimuli?

A

Mechanoreceptors sense stimuli due to physical deformation of their plasma membranes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is a free nerve ending? What are they sensitive to?

A

An unencapsulated dendrite of a sensory neuron; they are the most common nerve endings in skin. Free nerve endings are sensitive to painful stimuli, to hot and cold, and to light touch.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Meissner corpuscles;

a) location?
b) what type of skin?
c) what do they respond to?
d) encapsulated or not?
e) speed of adaptation?

A
  • a) Found in the upper dermis, but they project into the epidermis; sit between the dermal pupillae
  • b) Glabrous skin only; fingertips and eyelids
  • c) respond to fine touch/pressure and low frequency vibratinos
  • d) encapsulated
  • e) rapidly adapting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pacinian corpuscles;

a) location?
b) what type of skin?
c) what do they respond to?
d) encapsulated or not?
e) speed of adaptation?

A

a) Deep receptors located in subcutaneous tissue
b) Glabrous AND hairy skin
c) Respond to deep transient pressure and high frequency vibration
d) encapsulated
e) rapidly adapting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Ruffini endings;

a) location?
b) what type of skin?
c) what do they respond to?
d) encapsulated or not?
e) speed of adaptation?

A
  • a) located deep in dermis, long axis of the corpuscle is orientated parallel to the skin (20% of receptors in skin)
  • b) glabrous AND hairy skin
  • c) detect skin stretch and deformations within joints (provide valuable feedback for gripping objects and controlling finger position and movement)
  • d) encapsulated
  • e) slow adapting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Merkel’s discs;

a) location?
b) what type of skin?
c) what do they respond to?
d) encapsulated or not?
e) speed of adaptation?

A
  • a) found just beneath the epidermis; aligned with the pupillae
  • b) hairy AND glabrous skin
  • c) respond to light pressure/touch
  • d) unencapsulated
  • e) slow-adapting
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Diagram of sensory receptors in skin

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does the diameter of sensory afferents affect speed of conduction?

A

General principle;

  • Large diameter; rapidly conducting afferents (I/II)
  • Small diameter; slow conducting afferents (III/IV)

Conduction velocity is positively correlated with axon diameter.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

As a general principle, which receptors are sensory afferents with a large diameter associated with?

A

With low threshold mechanoreceptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

As a general principle, which receptors are sensory afferents with a small diameter associated with?

A

Associated with nociceptors and thermoreceptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

The configuration of the different types of receptors working in concert in the human skin results in a very refined sense of touch. Describe this configuration?

A
  • The nociceptive receptors are located near the surface.
  • Small, finely-calibrated mechanoreceptors (Merkel’s disks and Meissner’s corpuscles) are located in the upper layers and can precisely localize even gentle touch.
  • The large mechanoreceptors (Pacinian corpuscles and Ruffini endings) are located in the lower layers and respond to deeper touch.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

There are 2 types of nociceptive fibres. What are these?

A
  • A delta fibres
  • C fibres
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is first pain and second pain?

A

A single painful stimuli yields two successive and distinct sensations referred to as first and second pain sensation. First pain is brief, pricking, and well localised, whereas second pain is longer-lasting, burning, and less well localised.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Describe first pain. What fibres are involved? What receptors are involved?

A
  • Fast A delta fibres
  • Sharp or prickling
  • Easily localised
  • Occurs rapidly
  • Short duration
  • Mechanical or thermal nociceptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Describe 2nd pain. What fibres are involved? What receptors are involved?

A
  • Slow C-fibres
  • Dull ache, burning
  • Poorly localised
  • Slow onset
  • Persistent
  • Polymodal nociceptors
20
Q

Describe 1st and 2nd pain when treading on a pin

A
  1. The sharp stab is signaled via fast-conducting A-fibers, which project to the somatosensory cortex.
    1. This part of the cortex is somatotopically organised — the sensory signals are represented according to where in the body they stem from).
  2. The unpleasant ache you feel after the sharp pin stab is a separate, simultaneous signal sent from the nociceptors in your foot via thin C-pain to brain regions involved in processing of emotion and interoception
21
Q

What is the primary event in somatosensation?

A

Generation of an action potential in an afferent fibre ending

22
Q

Certain regulators of neuronal excitability are specific for nociceptive neurons. What are the 3 Voltage-Gated Sodium Channels that are almost exclusively expressed in nociceptors?

A
  1. Nav1.7
  2. Nav1.8
  3. Nav1.9
23
Q

What is congenital insensitivity to pain?

A

rare disease characterised by inability of experience to feel pain

24
Q

What is congenital insensitivity to pain (CIP) caused by?

A
  • Mutations within nociceptor-specific Voltage-Gated Sodium Channel Nav1.7
  • Inherited in an autosomal recessive pattern
25
Q

The inflammatory responseis characterised by what five classic symptoms?

A
  1. redness (rubor)
  2. heat (calor)
  3. swelling (tumor)
  4. pain or hypersensitivity (dolor)
  5. loss of function (functio lasea).
26
Q

How can inflammation lead to pain?

A
  • Inflammation produces overt pain through the direct activation of nociceptors
  • Inflammatory mediators can also reduce the threshold of activation of nociceptive sensory neurons, thereby producing peripheral sensitisation
27
Q

How can inflammatory mediators contribute to pain?

A

Inflammatory mediators interact with neurones to produce hypersensitivity

28
Q

What are the 4 actions of inflammatory mediators on peripheral terminals?

A
  1. Act to directly activate ligand-gated ion channels
    1. ATP, H+
  2. Act via activation of G-protein-coupled receptors
    1. Prostaglandins, Substance P, Bradykinin, Proteases, Histamine
  3. Act via activation of receptor tyrosine kinases
  4. ‘Gasotransmitters’
    1. NO, CO, H2S
29
Q

How is the dorsal horn organised? How does this influence the termination of somatosensory neurons?

A

The dorsal horn is organised in laminars. Different types of somatosensory neurons terminate at different lamina.

30
Q

Where do 2nd order nociceptive neurons project to?

A

The thalamus and then to the somatosensory cortex

31
Q

There are 2 conscious ascending tracts. What are these?

A
  1. Dorsal column-medial lemniscal pathway
  2. Spinothalamic pathway
32
Q

What ascending tract does most pain signals travel in?

A

Spinothalamic pathway

33
Q

What sensory deficits will be seen in a unilateral spinal lesion? (think DCML pathway AND spninothalamic pathway)

A
  • DCML –> A unilateral spinal lesion will produce sensory loss of touch, pressure, vibration and proprioception below the lesion on the same side
  • Spinothalamic –> vDiminished sensation of pain below the lesion will be observed on the opposite side.
  • vThis is called dissociated sensory loss.
34
Q

What is dissociated sensory loss?

A

Dissociated sensory loss is a pattern of neurological damage caused by a lesion to a single tract in the spinal cord which involves preservation of fine touch and proprioception with selective loss of pain and temperature.

35
Q

How is pain and temperature sensation from the face carried

A

By three peripheral nerve branches (V1, V2 and V3) of trigeminal nerve whose cell bodies sit in trigeminal ganglion (TG)

36
Q

Describe the pathway of 1st, 2nd and 3rd order afferent neurons carrying pain and temperature sensation from the face

A

Trigeminal System:

(5th Cranial nerve)

  1. •1st order afferents from face project to pars interpolaris & pars caudalis of medulla/upper cervical cord
  2. •2nd order neurones ascend contralaterally to thalamus (via trigemino-thalamic tract)
  3. •3rd order neurones project to cortex
37
Q

What is the gate control theory of pain?

A

The gate control theory of pain asserts that non-painful input closes the nerve “gates” to painful input, which prevents pain sensation from traveling to the central nervous system.

e.g. knife wound may not be painful

38
Q

What is central sensitisation?

A

Central sensitisation refers to the process through which a state of hyperexcitability is established in the central nervous system, leading to enhanced processing of nociceptive (pain) messages

39
Q

What is a familial hemiplegic migraine (FMH)?

A

Familial hemiplegic migraine (FHM) is an autosomal dominant type of hemiplegic migraine that typically includes weakness of half the body which can last for hours, days, or weeks. Also accompanied by visual disturbances known as aura.

40
Q

What is a migraine ‘aura’ caused by?

A

The aura is caused by cortical spreading depression (CSD) — a slowly advancing wave of tissue depolarisation in the cortex.

41
Q

More than half of FHM cases are caused by gain-of-function mutations within which gene?

A
  • Within the neuronal Cav2.1 Voltage-gated Ca2+ channel gene (CACNA1A)
  • The mutation results in increased Ca2+ flow into dendrites and excessive release of the excitatory neurotransmitter glutamate.
42
Q

What is cortical spreading depression (CSD)?

A

An electrophysiological phenomenon characterised by a wave of excitation followed by inhibition in cortical neurons - thought to cause migraine ‘aura’.

43
Q

Cause of cortical spreading depression?

A

Ignited by local elevation of extracellular K+ levels in pockets of intense excitatory transmission.

44
Q

How is the threshold for cortical spreading depression (CSD) affected in FMH patients?

A

The threshold for CSD initiation is reduced in FHM patients with mutations in the Cav2.1 Ca2+ channel because the higher Ca2+ level in dendrites facilitates glutamate release and thereby increases the likelihood that K+ levels will reach the CSD threshold.

45
Q

Both peripheral and central nociceptive pathways can be sensitised. What does this sensitisation lead to?

A

pathological pain states