(P7) Skin pathology (Lab27)

Question 1

Identify

Answer 1

Molluscum contagiosum

Question 2

Identify and Lable

Answer 2

Molluscum contagiosum

(circle) Scrab lesion-eosinophilic inclusion

(S2) Molluscum bodies (Poxyvirus) (eosinophilic inclusion cytoplasm-pink)-under/above epithelium

Note: Nuclei pushed to side

Question 3

Identify

Answer 3

Seborrheic keratosis

Question 4

Identify and Label

Answer 4

Seborrheic keratosis

(circled) Pseudo-horn cyst

(Blue stacked cells) Proliferation of Squamous Cells (Basal-like cells, hyperkeratosis, keratin-filled cycts on surface of tumor )

(red cicrcl) Horn-Cyst (fibroblast growth factor FGF-receprot)

(bottom red circl) proliferation of basolioid cell

Question 5

Identify and Label

Answer 5

Keratoacanthoma

Squamous proliferation tuor mainly on

Hair-bearing skin (long lasting keloid)

(yellow) Tumor cell proliferation

Question 6

Identify

Answer 6

Keratoacanthoma

Question 7

Identify and label

Answer 7

Keratoacanthoma

Question 8

Identify

Answer 8

Benign pilomatrixoma

Question 9

Identify and label

Answer 9

Benign pilomatrixoma

(red circl) Intratumor caclification

Ghost cells

Shadow cells

Question 10

Identify

Answer 10

Basal cell carcinoma

Question 11

Identify and Label

Answer 11

Basal cell carcinoma

Question 12

Identify

Answer 12

Pigmented compound nevus

Question 13

Identify and Label

Answer 13

Pigmented compound nevus

(Blue circl) melanocyte- darker

(3sld) nest of melanocyte-surrounded by cleft

Question 14

Identify

Answer 14

Malignant melanoma

Question 15

Identify and label

Answer 15

Malignant melanoma

Ballonin cell

Question 16

Identify

Answer 16

Keloid

Question 17

Identify and Label

Answer 17

Keloid

Question 18

Give an example of special staining helpful in detection of this lesion?

Answer 18

Keloid

-Van Gieson

Question 19

Q. Malignant neoplasm that originates from the same tissue is?

Answer 19

Molluscum contagiosum

-Squamous cell carcinoma-

Question 20

Q. Indicate the structure:

Large white/oval structure

Answer 20

Seborrheic keratosis

-Keratin filled cyst (horn cyst)-

Question 21

Q. The pathological differential diagnosis of this lestion should include?

Answer 21

Keratoacanthoma

-Squamous cell carcinoma-

Question 22

Q. This lesion typically occurs in the following age group?

Q. The lesion originates from what structure?

Q. List 2 benign skin tumors caused by viruses?

Q. Structure (Dark lower left) indicated on the slide is composed of?

Answer 22

Benign pilomatrixoma

• Children and young adults-
• Hair folicules-
• Verrucae, v. bulgaris, v. plantaris, v. plana, condyloma acuminatum, bowenoid papulosis, molluscum contagiousm-
• Calcium salt deposits-

Question 23

Q. is this lestion malignant, semimalignant, or benign?

Answer 23

• Basal cell carcinoma*
• Semimalignant-

Question 24

Q. This lesion typically unergoes slow evolution with time..name the lesion that represents the preceding and the next stage fo this evolution ?

Answer 24

• Basal cell carcinoma*
• -Marginal (junctinal) nevus-*
• -Dermal nevus-*

Question 25

Q. The malignant counterpart of this lesion is called?

Answer 25

• Basal cell carcinoma*
• -Malignant melanoma-*

Question 26

Q. The lesion direclty preceding this lesion is called?

Answer 26

• Pigmented compound nevus*
• Junctional nevus-

Question 27

Q. Name 2 systems commonly used for the evaluation of local extent of this lesion?

Answer 27

• Malignant melanoma*
• -Clark (level of invasion)*
• -Breslow (tumor thickness)*