(P4) Cardiac: Hyaline arteriolosclerosis of the kidney Flashcards
Identify Slide :
Hyaline arteriolosclerosis of the kidney
Hypertension** and **diabetes mellitus
Identify:
What causes this leasion?
Hyaline arteriolosclerosis of the kidney
-Chronic hypertension leads to reactive changes in the smaller arteries and arterioles throughout the body.
These changes are collectively referred to as arteriosclerosis.
-In the arterioles, the alterations are also known as arteriolosclerosis
Hyaline arteriolosclerosis of the kidney
What happens to the wall of the arterioles ?
- The wall of the arterioles is thickened by the deposition of basement membrane material and by the accumulation of plasma proteins
- The arterioles exhibit smooth muscle cell proliferation and increased amounts of intercellular* *collagen* and *glycosaminoglycans*, resulting in an *onion-skin appearance
Identify:
Glomeruli afferent arteriole:
Hyaline arteriolosclerosis of the kidney
_Glomeruli afferent arteriol_e:
- Hyaline arteriosclerosis in benign nephrosclerosis (benign hypertension)
- -Hyperplastic arteriosclerosis* in malignant hypertension:
a. Fibrinoid necrosis
b. Proliferation of intima with myxoid change
Hyaline arteriolosclerosis of the kidney
Microscopically;
The small muscular arteries display new layers of elastin.
Presenting as a reduplication of the internal elastic lamina* and *increased connective tissue
Hyaline arteriolosclerosis of the kidney
Macroscopically:
Macroscopically
- Thickening and hyalinization of the wall
- Smooth muscle cell proliferation – onion skin
- Narrowing of the lumen, regional scars in kidney parenchyma
Hyaline arteriolosclerosis of the kidney
-This lesion is most requently seen in what type of patients?
Most frequent: Heart patients, common in DM
Identify:
Identify:
Hyaline arteriolosclerosis of the kidney
Identify:
Hyaline arteriolosclerosis of the kidney
