(P4) Cardiac: Organizing Myocardial Infarct (251) Flashcards
Identify this slide
Organizing myocardial infarct
- Identify the Slide*
- identify*
- indentify*
- what type of inflammation*
- cardiomyocytes
- granulation tissue
- neutrophils
Name slide:
Organizing Myocardial Infarct
- rupture/aneurysm*
- pericarditis*
- mural thrombus*
- emboli*
Name this condition:
What causes this condition?
Organizing Myocardial Infarct
coronary artery occlusion, ulceration, fissuring
Locations of Infarct:
Organizing Myocardial Infarct
lateral or inferior or anterior wall
- of*
- l_eft ventricle_*
The most typical morphological complications
of this lesion are:
name 4
rupture/aneurysm
pericarditis
mural thrombus
emboli
Review:
Name Causes of
infarction
-coronary arterial occlusion-
o Coronary artery occlusion caused by change in the morphology of atheromatous plaque
Change in the
morphology of atheromatous plaque
cause what?
- intraplaque hemorrhage*
- ulceration*
- fissuring*
Organizing myocardial infarct
can causes what ?
name 3
- Infarction*
- occlusive thrombosis*
- coagulative necrosis*
Organizing myocardial infarct
Visible changes occure after _____hrs.
The necrotic are is replaced by what?
Visible gross changes after 18 hrs
Necrotic area replaced by granulation tissue
Connective tissue, fibroblast, inflammatory cells, thin vessels
Scar maturation – more collagen
In Organizing myocardial infarct
name complications after infarction:
(6)
arrhythmias
rupture
left ventricular heart failure
thromboemboli
aneurysm
Cardiac tamponade
Organizing myocardial infarct
name the location of the infarct:
- Left circumflex* – lateral wall of left ventricle (except apex)
- LAD* – anterior wall of left ventricle, near apex; anterior ventricular septum
Right coronary – inferior/posterior left ventricle; posterior ventricular septum
Hemorrhagic infarction
is found?
on the lateral wall of the left ventricle
Ischemic myocardial infarction
is found where?
Ischemic myocardial infarction
is found on the
ventricular septum
old myocardial infarction
is found?
from the ventricular septum to the part of the anterior wall are observed.
Organizing myocardial infarct
Macroscopy of:
- Old infarct:*
- Acute infarct:*
- 2nd week:*
- Old infarct* – fibrosis – white (granulation tissue)
- Acute infarct* – dark yellow mottling
- 2nd week* – collagen fibers deposit, scar formation begins
Name specifics:
name specifics:
Organizing myocardial infarct
Micro:
1. after first few hours: intracellular edema, begining coagulative necrosis
2. after 12hrs: ongoing necrosis, pyknosis of nuclei, hypereosinophilia, neutrophils infiltration
3. 3‐7days: necrotic myocytes digested by invading macrophages
- *4.** 7‐10 days: growth of granulation tissue
- *5.**from 2 week: progressive synthes is of collagen and fibrosis
