(P7) Lymphoid system pathology (Lab 29)

Question 1

Identify

Answer 1

Reactive lymphadenitis

Question 2

Q. Differential diagnosis of this lesion type of lymphoma is?

Answer 2

Reactive lymphadenitis

-Follicular lymphoma-

Question 3

Q. Macroscopic pattern of this lesion is?

Q. the area indicated on the slide is?

Answer 3

Reactive lymphadenitis

• -Germinal center and Manole Zone-*
• -Germinal center-*

Question 4

Identify

Answer 4

Hodgkin’s lymphoma

Question 5

Q. Name the most aggressive histological type of this lesion?

Answer 5

• Hodgkin’s lymphoma*
• Classical lymphocyte depleted HL-

Question 6

Q. The neoplastic cell typical of nodular lymphocyte predominant Hodgkin’s lymphoma is called?

Answer 6

Hodgkin’s lymphoma

-Popcorn cells (HL)-

Question 7

Hodgkin’s lymphoma

Name 5 subtypes:

Answer 7

1. Nodular sclerosis HL (NSHL)
2. Mixed cellularity HL (MCHL)
3. Lymphocyte rich HL
4. Lymphocyte depleted HL (most aggressive)
5. Nodular lymphocyte predominant HL (popcorn cell HL)

Question 8

Identify

Answer 8

Small lymphocytic lymphoma/chronic lymphocytic leukemia

Question 9

Q. The most typical clinical manifestation of this disease is?

Q. what is the main difference between SLL/CLL?

Answer 9

Small lymphocytic lymphoma/chronic lymphocytic leukemia

• Lymphodenopathy, hepatosplenomegaly, weight loss, anorexia, fatigue-
• difference is the degree of periphelar blood and bone marrow involvement…CLL is the most common leukemia of adults.

Question 10

Identify

Answer 10

Small lymphocytic lymphoma/chronic lymphocytic leukemia

Question 11

Identify

Answer 11

• Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue*
• (MALT lymphoma) (the stomach)*

Question 12

Q. The same lesion located in the:

salivary gland->

Thyroid gland->

Answer 12

Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue

(MALT lymphoma) (the stomach)

• SG = Sjogren’s syndrome (dry eyes/mouth)-condition often accompanies other immune system disorders; rheumatoid arthritis, lupus
• TG = Hashimoto dis (autoimmune dis. hypothyroidism)

Question 13

Label

Answer 13

Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) (the stomach)

Question 14

Identify

Answer 14

Follicular lymphoma

Question 15

Identify-

Name the growth pattern

and

2 principal cell types-

Answer 15

Follicular lymphoma

Question 16

Identify

Answer 16

Diffuse large B-cell lymphoma

Question 17

Q. Give 4 examples of mature B-Cell neoplasm (lymphomas)

Q. Name the pale area

Q. the large cells with nuclei are called

Answer 17

Diffuse large B-cell lymphoma

• 1. Burkitt*
• 2. Marginal Zone*
• 3. diffuse large, small, lymphatic, mantle*
• -Neioplastic areas are pale-*
• -Large cells w/nuclei = Centroblasts-*

Question 18

• Diffuse large B-cell lymphoma*
• Q. describe the cytologic features?*

Answer 18

Cytologic features:

• Centroblastic
• Immunoblastic (activated T-cells)
• Anaplastic

Note: aggressive =can treat

non-aggressive =cannot treat

Question 19

Label

Answer 19

Diffuse large B-cell lymphoma

Question 20

Identify

Answer 20

Mycosis fungoides

Question 21

Q. the structure indicated on the slide

Answer 21

Mycosis fungoides

-Pautrier’s microabscesses (aggreagates of atypical CD4 cells+ T-cells within the epidermis that are indicative of the disease)

Question 22

Q. Give 2 T-cell lymphoma?

Answer 22

Mycosis fungoides

-Mycosis fungoides-Sezary syndrome-anaplastic large cell lymphoma-

Question 23

Q. List 2 viruses associated with etiology of lymphomas?

Answer 23

Mycosis fungoides

• -Ebstein-Barr virus-*
• -Human T-Cel leukemia-*
• -Lymphoma virus (HTLV-1)*

Question 24

label

Answer 24

Mycosis fungoides