(P4) Resp Patho: Fibrocaseous tuberculosis of the lung

Question 1

Identify

Answer 1

Fibrocaseous tuberculosis of the lung

1. epithelioid cells*

2. Langhans Giant cells*

3. mycobacterium tuberculosis
4. The combination of parenchymal lesion and nodular involvement. The Ghon complex undergoes fibrosis and detectable calcification
5. granulomatous inflammation

Question 2

IDENTIFY SLIDE

What causes this lesion

and

how is it transmitted?

Answer 2

Fibrocaseous tuberculosis of the lung

Caused by mycobacterium tuberculosis

- Inhaled M. tuberculosis is deposited in the alveoli, usually in the lower and middle lobes and

anterior segments of upper lobes.

-Generally transmitted from person to person by aerosolized droplets

Question 3

Identify this slide:

What type of lesion is this

and

what type of Cells are primarily found?

Answer 3

Fibrocaseous tuberculosis of the lung

Caseous granuloma – classic lesion of TB

-Soft, semisolid core surrounded by epithelioid cells*, *Langhans giant cells, lymphocytes and peripheral fibrous tissue

▪ Caseous necrosis in center:

–>This is why this form of TB is called fibrocaseous TB

Question 4

Describe the Gross appearance and Microscopy

of

Fibrocaseous tuberculosis of the lung

Answer 4

• Gross:*
• Large nodule (white, chalky appearance), caseous necrosis. Granuloma at the edge
• Slide:*
• Edges of necrosis fibrosis (fibrous connective tissue surrounds granulomas). Lesions are large

(unlike in military tuberculosis)

Question 6

Identify:

Answer 6

Question 7

Identify:

Answer 7

Question 8

Identify :

Answer 8

Fibrocaseous tuberculosis of the lung