Orlistat Flashcards
When to give Orlistat 60mg
if BMI is above 28
When to not give Orlistat
When taking:
- Levothyroxine
- Amiodarone
- Ciclosporin
- Warfarin + NOACs
- Acarbose
- Anti-epileptics
How do Orlistat and Levothyroxine interact
reduces control of hypothyroidism
How do Orlistat and Amiodarione interact
decreases plasma levels of orlistat
How do Orlistat and Ciclosporin interact
decrease plasma levels of orlistat
How do Orlistat and Warfarin and NOACs interact
INR affected by low vitamin K
How do Orlistat and Anti-epileptics interact
increase risk of convulsions
Why should you advice caution if a patient is taking orlistat and oral contraceptive
increase diarrhoea
- take antidiarrhoeal
Why should you advice caution if a patient is taking orlistat and has ADEK vitamin deficiency
impaired absorption of fat soluble vitamins
- take vitamin supplements and night or 2 hour +- orlistat dose
Which conditions should be a referral if a patient is in need of orlistat
- diabetes mellitus
- hypertension
- high cholesterol
- chronic malabsorption syndrome
- cholestatis (flow of bile from liver is blocked)
- pregnancy or breastfeeding
- kidney disease
- failure to lose weight after 3 months
Orlistat OTC supply criteria
- BMI obove 28
- 18+
- 6 months in conjunction with lower fat diet
How does Orlistat work
Potent lipase inhibitor, preventing absorption of dietary fat
How to take Orlistat
ONE 60mg capsule TDS
- before three main meals or up to 1 hour after
- omit dose of meal had no fat or skipped
Side effects of Orlistat
- oily stools
- faecal incontinece
Advice when taking orlistat
- not a substitute for healthy diet and exercise
- 5 portions of fruit and veg
- 18 to 30g of fibre per day
- 2.5L of fluids
-Alcohol 2 to 3 units a day interspaces with alcohol free days
(14 units max)
