OCD Flashcards

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1
Q

What is OCD

A

an anxiety disorder, characterised by irrational, persistent and intrusive thoughts (obsessions) and intense, uncontrollable urges to complete tasks (compulsions)

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2
Q

Behavioural characteristics of OCD

A
  • COMPULSIONS, they are repetitive (compelled to repeat a behaviour) and they reduce anxiety by performing these obsessions
  • AVOIDANCE, sufferers may try to reduce anxiety by staying away from situations. For example, the sufferer may have irrational thoughts about germs in a bin so they don’t go near it
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3
Q

Emotional characteristics of OCD

A
  • ANXIETY AND DISTRESS, caused by powerful axiety DEPRESSION obsessions and compulsions
  • DEPRESSION, due to discomfort and interference
  • GUILT AND DISGUST, directed internally or externally at the world
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4
Q

Cognitive characteristics of OCD

A
  • OBSESSIVE THOUGHTS: 90% of OCD sufferers main cognitive features recur over and over
  • COGNITIVE STRATEGIES: sufferers can respond to obsessive thoughts by using cognitive coping stragetiesm
  • INSIGHT TO EXCESSIVE ANXIETY: sufferers are aware that their obsessions and compulsions are irrational
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5
Q

OCD CYCLE

A

obsessive thoughts

Anxiety

Compulsive behaviour

Temporary relief

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6
Q

Concordance rate

A

Measure of genetic similarity

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7
Q

Dompamine

A

A key neurotransmitter in the brain which effects motivation and drive

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8
Q

Serotonin

A

Another neurotranmitter which is believed to have an effect on mood regulation

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9
Q

Diathesis stress model

A

psychological theory that explains mental disorders as a result of a combination of environmental stressors and a person’s inherent vulnerability

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10
Q

What is the COMT gene

A

The gene is associated with the production of an enzyme that regulates the function of dopamine

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11
Q

What does the variation of the COMT gene do

A

Decreases the amount of COMT available and so dopamine is not controlled and there is probably too much dopamine (associated with OCD)

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12
Q

Why does too much dopamine cause OCD

A

Because it potentially disrupts the brains reward system leading to an increased focus on repetitive behaviors (compulsions) that are aimed at achieving a sense of relief from anxiety caused by intrusive thoughts (obsessions)

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13
Q

What does SERT gene do

A

Affects the transport of serotonin

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14
Q

What happens to people’s sert gene with OCD

A

the sert gene mutates, causing an increase in transporter proteins at a neurons membrane, leads to an increase in the REUPTAKE of serotonin into the neuron which decreases levels of serotonin

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15
Q

How does little serotonin cause ocd

A

If you don’t have much serotonin floating around in your brain, you might feel depressed or anxious which could lead to ocd

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16
Q

What are candidate genes .

A

Candidate genes are the genes which create vulnerability for OCD e,g COMT and sent

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17
Q

What does it mean by saying OCD is polygenic

A

Not a single gene implicates OCD, multiple do. Complex and unclear disorder.

Taylor (2013) meta analysis found evidence of up to 230 different genes involved with OCD

18
Q

What does aetiologically heterogeneous mean

A

Different types of OCD, a number of different colonisations of genes

19
Q

Supporting evidence of biological explanations of OCD

A

Family studies (Lewis 1936)

Twin studies (nestadt et al 2010)

20
Q

Family studies

A

Lewis 1936’ assessed ocd sufferers and found that 37% had parents who also had the disorder. 21% of sufferers also had siblings who had the disorder

21
Q

Twin studies

A

Nestadt et al 2010, reviewed twin studies examining OCD, found concordance rate of 68% in identical twins, and 31% of non identical twins

22
Q

Positives of biological explanation of OCD

A
  • good supporting evidence, but concordance rate is not 100% so environment must play a role
23
Q

Negatives of biological explanation to OCD

A
  • too many candidate genes which means they can’t provide a useful, predictive value for the disorder
  • culturally transmitted, families may be more vulnerable to OCD as the family members may observe and imitate each ither’s behabiour
24
Q

OFC

A

Orbitofontrol cortex

25
Q

Worry circuit

A
  1. OFC notices when something is wrong
  2. OFC sends signals to the thalamus about this that are worrying
  3. The caudate nucleus (in basal ganglia) is in between and it regulates the signals from OCD, so thalamus doesn’t get hyperactive
26
Q

Worry circuit for someone with ocd

A

When caudate nucleus is damaged or abnormal, it fails to suppress worries. Thalamus is alerted which sends signals back to OFC. anxiety and impulsive behaviours occur

27
Q

Animal Research supporting dopamine to do with OCD

A

Szechtman et al 198

High dose of drugs enhance dopamine induce movement resembling compulsive behaviours found in OCD (animal study)

28
Q

Research supporting serotonin role in OCD

A

Antidepressant drugs that increase serotonin activity have been seen to reduce OCD symptoms

29
Q

Research supporting worry circuit

A

Surgery which disconnects the basal ganglia from the frontal cortex can reduce symptoms of severe OCD

30
Q

3 biological explanations of OCD

A

SERT
COMT
WORRY CIRCUIT

31
Q

What does drug therapy aim to do

A

Increase or decrease levels, or activity of neurotransmitters in the brain

32
Q

What does SSRIs stand for

A

Selective serotonin reuptake inhibitor. Work on the serotonin system in the brain. Available in liquid or capsules. Takes up to 3 to 4 months of daily use

33
Q

3 types of SSRIs

A
  • citalopram
  • escitalopram
  • fluoxetine
34
Q

Combination of SSRI and CBT

A

1 - SSRIs biological intervention. Can reduce symptoms enough to be able to engage with taking therapy

2 - CBT, cognitive intervention, can help sufferers learn to cognitively cope with their obsessions and compulsions

35
Q

SNRIs

A

Serotonin-noradrenaline reuptake inhibitors

36
Q

What do SNRIs do

A

Increase serotonin and noradrenaline, used to treat OCD for patients who don’t respond to SSRIs

37
Q

3 drugs to treat OCD

A
  • SSRIs
  • SNRIs
  • tricyclics
38
Q

What are tricyclics

A

Older type of antidepressant. Same effect on serotonin as SSRIs. More severe side effects only used if SSRIs aren’t effective

39
Q

Positives of drug treatment for OCD

A
  • effective alleviation of symptoms

Clear evidence showing SSRIs are effective in reducing severity of OCD symptoms

Decline by 70% after SSRIs

  • cheap compared to therapy, don’t disrupt patients lives, no hard work
40
Q

negatives of drug treatment for OCD

A
  • side effects, e.g blurred vision