Mutations - molecular mech

Question 1

Where?

Answer 1

• Promotor
• Regulatory sequences – Coding region
• Introns – not as dangerous (non coding)

Question 2

What kind?

Answer 2

• Gene mutations
• Chromosome m.
• Genome m

Question 3

Gene mutations:

Answer 3

single base substitutions- silent m. (code for same AA), missense m. (code for diff.
AA), nonsense m. (STOP codon)

Question 4

Frame shift mutations?

Results in?

Answer 4

• insertion (insert one or more nucleotides, changes
  sequence + codes diff AA downstream), deletion (loss of one or more nucleotides,
  changes sequence + codes diff AA downstream)
  creates non functioning or different function protein.