Cell cycle checkpoints Flashcards
1
Q
Checkpoints are activated by?
A
cell damage, mutation + can delay cell progression to allow DNA to repair
2
Q
Checkpoints are at?
A
G1, G2 + M phases -restriction point
3
Q
Important restriction point is?
A
at end of G1 phase, p53 protein
coded by tp53 tumour suppressor gene.
4
Q
If DNA irreparable?
A
permanent cell arrest and apoptosis
5
Q
Essential components for checkpoints?
A
ATT, ATM, ChK1, ChK2
6
Q
STOP cell cycle
A
ATR-ChK1
ATM-ChK2
7
Q
DNA mismatch repair system
A
recognizing + repairing erroneous insertion,
deletion, + mis-incorporation of bases that can arise during DNA replication +
recombination, as well as repairing some forms of DNA damage
