Muscle Flashcards
What are the 3 types of Muscle tissue found in the body?
Skeletal
Cardiac
Smooth
Skeletal Muscle has all of the following characteristics except:
- Striated
- Conscious control
- Excitated by Self-depolarization
- Functions in locomotion and heat generation
- Excitated by Self-Depolarization is false
- Actually excited by somatic, alpha motor neurons
Cardiac Muscle has all of the following characteristics except…
- Unstriated Muscle
- Found in the heart
- Involuntary Control
- Function is to pump blood through the circulatory system
- Unstriated muscle is false!
- Cardiac muscole is striated like skeletal muscle
Smooth muscle has all of the following characteristics except…
- Nonstriated
- Involuntary control
- Excited by several different mechanisms - stretching, neuronal activity etc…
- Found only in the GI tract
- Found only in GI tract would be FALSE
- It is found throughout the body
Skeletal muscle is innervated by neurons from the [] [] of the spinal cord
Ventral Horn
What is the name of 1 skeletal muscle cell?
Myofiber
What is the organziation of a muscle fiber, from largest “cell to smallest unit”…
Myofiber > Myofibril > sarcomere > microfilament (actin/myosin)
What is the contractile unit of a myofiber?
Sarcomere
The sarcolemma is another name for the [] [] of the muscle cell…
Plasma Membrane
Transverse Tubules
- [] of the sarcolemma
- Connect the myofiber to the []
- Allow for the quick delivery system for the spread of [] [] to the skeletal muscle cell
- Closely associated with the [] [] which spreads throughout the entire cell
- Invaginations
- extracellular
- action potentials
- sarcoplastic reticulum
What is the thick filament in a myofibril and what is the thin filament?
- thick = myosin
- Thin - actin
[] [] is the intracellular storage site of Ca2+ for T-tubule usage?
Sarcoplastic Reticulum (SR)
Myosin is formed by…
2 [] [] of myosin that form the head, neck, and tail
Heavy Chains
How many heads does Myosin have?
What binding sites are on the myosin head?
- 2 heads
- Each head has an actin binding site
- Both have ATPase sites which hydrolyze ATP
- Both have 2 Light chains
What are the 2 light chains on each of the myosin heads?
- Alkali Light chain - serves a structural role
- Regulatory myosin light chain
- regulates the ATPase capability of the myosin head
What molecules make up the double helical actin structure in muscle cells?
- G-actin molecules come to gether to make F-Actin molecules
- F-actin chains make the double helix structure
What 2 regulatory proteins are on actin that inhibit/prohibit muscle contractions?
- Tropomyosin
- Troponin
What are the binding sites of Troponin and what does each site bind?
- TnC - binds to calcium
- TnT - binds to tropomyosin
- TnI - binds to actin and inhibits actin/myosin interaction
Which actin regulatory protein physically blocks the binding of acting to myosin?
Which actin regulatory protein removes the barrier stopping acting/myosin binding?
- Tropomyosin
- Troponin
What is the sequence of events that removes tropomyosin from the myosin binding sites on the actin molecule?
- Ca2+ binds to the TnC subunit of troponin
- Conformational change in troponin
- This conformational change moves tropomyosin out of the way
- Myosin can bind to Actin
This portion of the the sarcomere stretches in between adjacent A-Bands…
The I band
The I-band consists of only [] filament, or [], and stretches between two adjacent []
- thin filament
- Actin
- sarcomeres
[] - [] anchor points for the thin filaments and the boundaries for the sarcomeres…
Z-Discs
The []-zone contains only thick filaments and does not overlap with [] filaments
- H-Zone
- Thin Filaments