Cardiac - Pt 2 Flashcards
What are the phases of the Nodal Action Potential?
Phase 4
Phase 0
Phase 3
What is the main characteristic of Phase 4 in the Nodal Action Potential?
- Possesses an unstable membrane potential caused by the the “Funny Current”
The “Funny Current” is caused by….
- Due to the Na+ influx from voltage-gated, non-selective cation channels.
- These channels open in response to the previous action potential.
What is the main characteristic of Phase 0 in the Nodal Action Potential curve?
- It is the rapid depolarization of the cell.
- This is due to Voltage-Gated L-type Ca2+ channels opening, and Ca2+ rushing into the cell.
What type of channels cause the upstroke in the nodal action potential?
The opening of Voltage-gated, L-type Ca2+ channels
What cation(s) is responsible for the Ventricular Upstroke?
What cation(s) is responsible for the Nodal upstroke?
- Na+/Ca2+
- Ca2+
What is the main characteristic of Phase 3 in the Nodal Action Potential?
Repolarization occurs via potassium rushing out of the cell down its electrochemical gradient.
What causes the absolute refractory period in ventricular cardiac cells?
The inactivation of Na+ voltage gated channels (just like in muscle cells)
What is the Supranormal period in the nodal action potential curve?
- The cell is hyper excitable, to where even a weak stimulus could cause an AP.
What do the Chordae Tendineae do for Semilunar valves in the heart?
Where are they attached?
- First - the chordae tendineae supports AV valves so they do not open backwards. Not, semilunar valves
- They are attached to the AV valves and papillary muscles
What happens to the AV valves when ventricular pressure exceeds Atrial pressure?
AV valves close
Why does the mitral valve close before the Tricuspid Valve during a heart contraction?
Because the pressure gradient caused by the Left Ventricle is greater than the pressure gradient caused by the right ventricle.
T/F
Chordae Tendineae help to close AV valves?
False
The chordae Tendineae only support the AV valves from swinigng upward into the atria
What is the Frank-Starling relationship?
- “States that the volume of blood ejected by the bentricle depends on the volume present in the ventricle at the end of diastole”
T/F
As heart filling increases, stretch increases, and less systolic force will be generated during contraction - resulting in a decreased stroke volume
FALSE
This is opposite of the Frank Sterling Law.
When stretching increases, more systolic foce will be generated and it will increase stroke volume
T/F
Heart Sounds are caused by valves?
False
They are caused by turbulence of blood vibrating chamber walls!